61426

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 288049..289091 Replicon chromosome
Accession NZ_CP014546
Organism Pseudomonas azotoformans strain S4

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A127HR52
Locus tag AYR47_RS01385 Protein ID WP_061434001.1
Coordinates 288049..288624 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID W2E1E2
Locus tag AYR47_RS01390 Protein ID WP_033896244.1
Coordinates 288621..289091 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYR47_RS01350 283466..284002 - 537 WP_061433999.1 sigma-70 family RNA polymerase sigma factor -
AYR47_RS01355 284182..284511 + 330 WP_033896249.1 hypothetical protein -
AYR47_RS01360 284473..285120 - 648 WP_051421931.1 LysE family transporter -
AYR47_RS01365 285146..285952 - 807 WP_061434000.1 2OG-Fe(II) oxygenase family protein -
AYR47_RS01370 286185..286878 + 694 Protein_275 helix-turn-helix domain-containing protein -
AYR47_RS01375 286881..287516 - 636 WP_033896246.1 LysE family translocator -
AYR47_RS01380 287644..288015 + 372 WP_016979611.1 PH domain-containing protein -
AYR47_RS01385 288049..288624 - 576 WP_061434001.1 PIN domain-containing protein Toxin
AYR47_RS01390 288621..289091 - 471 WP_033896244.1 helix-turn-helix domain-containing protein Antitoxin
AYR47_RS01395 289301..289873 - 573 WP_061434002.1 hypothetical protein -
AYR47_RS01400 289943..291298 - 1356 WP_061434003.1 sensor histidine kinase -
AYR47_RS01405 291295..291957 - 663 WP_033896241.1 response regulator -
AYR47_RS01410 292105..292371 + 267 WP_033896240.1 PepSY domain-containing protein -
AYR47_RS01415 292371..292916 + 546 WP_061434005.1 cytochrome b/b6 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21672.05 Da        Isoelectric Point: 4.8780

>T61426 WP_061434001.1 NZ_CP014546:c288624-288049 [Pseudomonas azotoformans]
MRCSPFTAVYDACVLYPAALRDLLMWLGLSGLYRARWTSQIHEEWKRNVLKNRPDLTAEQVNCTSELMDKAIPDALVTGY
EDLCSILDLPDPDDRHVLAAAIRSKAEVIVTFNLKDFPPHILAAYDIEPMHPDDFISDLWDLDQAAVLGAAQKQRRALRR
PPMEAGNYLEMLMRQGLVQTSKVLGPYEVML

Download         Length: 576 bp

>T61426 NZ_CP014546:c288624-288049 [Pseudomonas azotoformans]
ATGAGGTGTTCGCCTTTTACCGCTGTATATGATGCTTGTGTTCTCTACCCGGCGGCGCTTAGGGATTTGCTGATGTGGCT
TGGCTTGTCAGGGTTGTATCGAGCGAGATGGACTAGCCAGATCCATGAGGAGTGGAAGCGCAACGTACTCAAAAACCGGC
CCGACCTCACGGCTGAGCAAGTGAATTGCACGTCTGAGTTGATGGACAAGGCCATACCTGACGCTTTGGTTACGGGGTAC
GAGGACTTGTGTTCGATTTTGGATTTGCCTGACCCTGACGATCGTCACGTGCTGGCCGCTGCGATACGAAGCAAGGCTGA
GGTGATCGTAACCTTCAACTTGAAAGACTTTCCACCGCACATCCTGGCAGCTTATGACATTGAGCCGATGCATCCGGATG
ACTTTATTTCGGATCTTTGGGATCTGGATCAGGCGGCGGTGTTGGGTGCGGCGCAGAAACAAAGGCGGGCGTTGAGGCGA
CCTCCGATGGAGGCGGGGAATTATCTAGAGATGTTGATGCGGCAGGGGTTGGTGCAGACGAGTAAGGTACTGGGGCCTTA
TGAAGTGATGTTGTAG

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17434.19 Da        Isoelectric Point: 6.9936

>AT61426 WP_033896244.1 NZ_CP014546:c289091-288621 [Pseudomonas azotoformans]
MITNHLPKTILPLEKEVEAAVQGQRELASLLSTKFETQRIDIFDKEDKPHTLVLPTSALRLLVDILGELAIGNAVKVVPV
HAELTSQEAADLLNVSRPHLVKMLEEGAIPFTKTGRHRRIRFSDLMAFKQRRAEESQRAMEALAKQAQELGMGYDG

Download         Length: 471 bp

>AT61426 NZ_CP014546:c289091-288621 [Pseudomonas azotoformans]
ATGATCACCAACCACCTTCCCAAAACGATCCTTCCGCTGGAAAAGGAAGTCGAAGCGGCCGTACAAGGTCAGCGCGAATT
GGCGTCTCTGTTGTCGACCAAATTCGAAACCCAGCGAATCGATATCTTCGACAAAGAAGACAAGCCCCACACCCTCGTAC
TCCCAACCTCAGCACTGCGCTTGTTGGTGGATATCCTGGGCGAGTTGGCTATCGGCAATGCCGTCAAGGTAGTCCCTGTG
CATGCTGAACTCACCTCGCAGGAGGCCGCCGACCTGCTTAACGTTTCACGGCCGCACTTGGTCAAGATGCTGGAGGAAGG
TGCCATTCCCTTTACAAAAACCGGTCGACATCGGCGAATCCGGTTTTCGGATTTGATGGCGTTCAAGCAGAGGCGAGCTG
AGGAAAGCCAGAGAGCAATGGAGGCGCTTGCTAAACAGGCCCAGGAGTTGGGAATGGGGTATGACGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127HR52

Antitoxin

Source ID Structure
AlphaFold DB W2E1E2

References