Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1752637..1753242 Replicon chromosome
Accession NZ_CP014545
Organism Sphingorhabdus sp. M41

Toxin (Protein)


Gene name vapC Uniprot ID A0A127MFD1
Locus tag AZE99_RS08340 Protein ID WP_067199773.1
Coordinates 1752637..1753002 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A127MF34
Locus tag AZE99_RS08345 Protein ID WP_067199776.1
Coordinates 1753009..1753242 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AZE99_RS08320 1748541..1749092 - 552 WP_067199761.1 GDYXXLXY domain-containing protein -
AZE99_RS08325 1749089..1750258 - 1170 WP_067199764.1 DUF2157 domain-containing protein -
AZE99_RS08330 1750351..1750791 - 441 WP_067199766.1 OsmC family protein -
AZE99_RS08335 1750794..1752617 - 1824 WP_067199771.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
AZE99_RS08340 1752637..1753002 - 366 WP_067199773.1 type II toxin-antitoxin system VapC family toxin Toxin
AZE99_RS08345 1753009..1753242 - 234 WP_067199776.1 ribbon-helix-helix protein, CopG family Antitoxin
AZE99_RS08350 1753393..1754040 - 648 WP_067199778.1 hypothetical protein -
AZE99_RS08355 1754037..1755395 - 1359 WP_067199781.1 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU -
AZE99_RS08360 1755508..1756539 - 1032 WP_067203447.1 nucleotidyltransferase family protein -
AZE99_RS08365 1756539..1757399 - 861 WP_067203445.1 HprK-related kinase A -
AZE99_RS08370 1757408..1757692 - 285 WP_067199783.1 HPr-rel-A system PqqD family peptide chaperone -
AZE99_RS08375 1757765..1758181 - 417 WP_067203449.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-36)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13656.81 Da        Isoelectric Point: 7.0129

>T61424 WP_067199773.1 NZ_CP014545:c1753002-1752637 [Sphingorhabdus sp. M41]
MSTPFFDTNIIIDWLQDRPGAAAELQRYAKHRISRIVWTEVMAGEPLETRRNVQDLLSPFEIVELDARIGDAAADIRYRT
GMKLLDAMILATAQINGAILITRNTKNFPANMPGIRIPYSL

Download         Length: 366 bp

>T61424 NZ_CP014545:c1753002-1752637 [Sphingorhabdus sp. M41]
ATGTCCACACCCTTCTTCGACACCAATATCATCATTGACTGGCTTCAGGACCGGCCCGGTGCGGCGGCCGAGTTGCAGCG
CTATGCAAAGCATAGAATTAGCCGCATTGTCTGGACGGAAGTGATGGCAGGAGAACCATTGGAGACCCGGCGCAACGTGC
AGGATCTGCTGTCTCCGTTCGAAATCGTCGAACTGGATGCACGAATAGGTGATGCAGCGGCGGATATCCGCTATCGGACA
GGGATGAAGCTCCTTGATGCGATGATACTTGCTACTGCGCAGATCAATGGTGCTATCTTGATTACGCGGAACACAAAGAA
TTTCCCGGCCAATATGCCGGGCATCCGGATACCTTATAGCCTCTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8725.68 Da        Isoelectric Point: 5.1333

>AT61424 WP_067199776.1 NZ_CP014545:c1753242-1753009 [Sphingorhabdus sp. M41]
MTRILADLPEDDVKWLDAQAAEQGKSRAQLLREAVAGFRAEASKDWISKGRGYWKDRDDIGDSVAYQRAIRADREST

Download         Length: 234 bp

>AT61424 NZ_CP014545:c1753242-1753009 [Sphingorhabdus sp. M41]
ATGACCCGTATCCTGGCAGACCTTCCCGAAGATGATGTGAAATGGCTCGACGCGCAAGCAGCAGAGCAGGGAAAATCGCG
GGCGCAGTTGCTGCGGGAGGCAGTAGCCGGTTTTCGCGCCGAAGCAAGCAAGGACTGGATTTCCAAAGGTCGCGGATATT
GGAAGGATCGCGATGATATTGGTGACAGCGTCGCATATCAGCGTGCAATCCGCGCCGACCGCGAATCCACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127MFD1

Antitoxin

Source ID Structure
AlphaFold DB A0A127MF34

References