Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-DUF971
Location 873930..874555 Replicon chromosome
Accession NZ_CP014545
Organism Sphingorhabdus sp. M41

Toxin (Protein)


Gene name PumA Uniprot ID A0A127MD35
Locus tag AZE99_RS04165 Protein ID WP_067198311.1
Coordinates 873930..874223 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A127MD14
Locus tag AZE99_RS04170 Protein ID WP_067198313.1
Coordinates 874274..874555 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AZE99_RS04145 871253..871645 + 393 WP_067198304.1 host attachment family protein -
AZE99_RS04150 871912..872271 + 360 WP_067198306.1 hypothetical protein -
AZE99_RS04155 872623..872904 + 282 WP_067198308.1 hypothetical protein -
AZE99_RS04160 873156..873788 + 633 WP_082788232.1 hemolysin III family protein -
AZE99_RS04165 873930..874223 + 294 WP_067198311.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AZE99_RS04170 874274..874555 + 282 WP_067198313.1 putative addiction module antidote protein Antitoxin
AZE99_RS04175 874572..876014 - 1443 WP_067198315.1 hypothetical protein -
AZE99_RS04180 876288..876659 + 372 WP_067198316.1 30S ribosomal protein S12 -
AZE99_RS04185 876683..877153 + 471 WP_067198318.1 30S ribosomal protein S7 -
AZE99_RS04190 877355..879448 + 2094 WP_067198319.1 elongation factor G -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-94)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.6803

>T61423 WP_067198311.1 NZ_CP014545:873930-874223 [Sphingorhabdus sp. M41]
MNIRQTDAFANWLKKLKDHEARARIIMRVNRFRFGNLGDVKAVGDGVREARIDYGPGYRLYFVERRGELIILLCGGSKKT
QQSDIAMAKTLKRDVDI

Download         Length: 294 bp

>T61423 NZ_CP014545:873930-874223 [Sphingorhabdus sp. M41]
ATGAATATTCGGCAGACCGACGCCTTTGCGAATTGGCTCAAGAAGCTGAAGGATCATGAGGCGCGGGCGCGGATCATTAT
GCGCGTCAATCGTTTTCGCTTCGGCAATCTTGGTGATGTGAAAGCGGTGGGTGACGGGGTCCGTGAGGCACGTATTGATT
ATGGTCCCGGCTACCGACTTTATTTTGTCGAGCGTAGAGGCGAATTGATCATATTGCTTTGCGGGGGATCGAAGAAAACG
CAGCAAAGTGATATCGCAATGGCAAAAACATTGAAGAGAGACGTTGACATATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 9912.40 Da        Isoelectric Point: 4.7063

>AT61423 WP_067198313.1 NZ_CP014545:874274-874555 [Sphingorhabdus sp. M41]
MATTTTEFDAAEYLDSPEMIATYLKVAFEENDAALIRTALNDVARAKGMTAVAAESKITRQALYKALGPNGNMTLETLLG
VLRAMGVRLSVSG

Download         Length: 282 bp

>AT61423 NZ_CP014545:874274-874555 [Sphingorhabdus sp. M41]
ATGGCGACCACGACAACAGAATTCGACGCTGCCGAATATCTCGACAGCCCGGAAATGATCGCGACCTATTTGAAGGTTGC
CTTCGAAGAAAATGACGCCGCGCTGATCCGCACCGCGCTGAACGATGTCGCGCGCGCCAAGGGTATGACGGCGGTGGCAG
CGGAGAGCAAGATCACGCGGCAGGCGCTGTACAAGGCGCTGGGTCCGAATGGCAATATGACGCTGGAGACCTTGCTTGGG
GTGCTGCGAGCGATGGGGGTGCGGTTGTCGGTTAGTGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127MD35

Antitoxin

Source ID Structure
AlphaFold DB A0A127MD14

References