Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) sdenTA/AbiEii(toxin)
Location 4017167..4018581 Replicon chromosome
Accession NZ_CP014544
Organism Zhongshania aliphaticivorans strain SM-2

Toxin (Protein)


Gene name sdenT Uniprot ID A0A127MA18
Locus tag AZF00_RS17955 Protein ID WP_062384550.1
Coordinates 4017167..4018054 (-) Length 296 a.a.

Antitoxin (Protein)


Gene name sdenA Uniprot ID A0A127M9Z3
Locus tag AZF00_RS17960 Protein ID WP_062384553.1
Coordinates 4018057..4018581 (-) Length 175 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AZF00_RS17930 4013936..4014994 - 1059 WP_008252831.1 macro domain-containing protein -
AZF00_RS17935 4015046..4015687 - 642 WP_008252832.1 DUF4433 domain-containing protein -
AZF00_RS17940 4015688..4016272 - 585 WP_008252833.1 restriction endonuclease subunit S -
AZF00_RS17945 4016303..4016485 - 183 WP_008252834.1 hypothetical protein -
AZF00_RS17950 4016485..4016655 - 171 WP_008252835.1 helix-turn-helix transcriptional regulator -
AZF00_RS17955 4017167..4018054 - 888 WP_062384550.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
AZF00_RS17960 4018057..4018581 - 525 WP_062384553.1 hypothetical protein Antitoxin
AZF00_RS17965 4019088..4019705 + 618 WP_062384556.1 guanylate kinase -
AZF00_RS17970 4019789..4020052 + 264 WP_008252847.1 DNA-directed RNA polymerase subunit omega -
AZF00_RS17975 4020075..4022255 + 2181 WP_062384559.1 RelA/SpoT family protein -
AZF00_RS17980 4022360..4022743 + 384 WP_062384562.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - pilH / pilG / pilU / pilT 3882740..4042395 159655


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-265)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 296 a.a.        Molecular weight: 34128.15 Da        Isoelectric Point: 5.9920

>T61422 WP_062384550.1 NZ_CP014544:c4018054-4017167 [Zhongshania aliphaticivorans]
MLKQQIRQIVQSNPDFAAVTPVIEKEILHHDIMDVLIKQGVMQRLTFIGGTSLRMCYNSSRLSEDLDFNGGYDFKPSEFE
GLESEIQTYIQNKYETEVWVNKPSSEQQGDTVSWKISIVKEPNRPDLPRQKMHIDVCAIPSFDIEKRPLINHYDIVVPTE
GILVPVQSLQETLADKLIALAYRARRIKPRDIWDIVWIKQRGIDLSKVLVDKKLTARHKQTDDFRQALSTALAKLMTEEE
VRNDFNMEISRFIPKQIKERTLDSPEYWTYVQGEVNAIVSELLHDGTPKKPFDMG

Download         Length: 888 bp

>T61422 NZ_CP014544:c4018054-4017167 [Zhongshania aliphaticivorans]
ATGCTGAAGCAACAAATTCGCCAAATCGTACAGTCAAACCCTGACTTTGCAGCAGTAACGCCCGTGATAGAAAAAGAGAT
CTTGCATCACGACATTATGGACGTGCTGATCAAGCAAGGCGTTATGCAGCGATTAACCTTTATTGGCGGCACCTCATTAC
GCATGTGTTACAACAGTAGTAGGTTGTCAGAGGATCTTGATTTCAACGGCGGCTATGACTTCAAGCCATCCGAGTTTGAA
GGGTTGGAGTCCGAGATCCAGACCTATATTCAAAATAAGTATGAAACCGAAGTTTGGGTAAACAAGCCCTCTAGCGAGCA
GCAAGGAGATACTGTTTCGTGGAAGATTAGTATCGTGAAAGAGCCTAATCGTCCTGATTTACCACGACAAAAAATGCATA
TTGACGTCTGTGCAATACCCTCATTCGATATCGAAAAGCGTCCGTTAATCAATCATTACGACATTGTTGTGCCGACTGAA
GGGATCTTGGTTCCGGTGCAGTCATTACAAGAAACACTGGCCGATAAGCTTATTGCGTTAGCGTATCGGGCAAGACGTAT
CAAGCCTCGTGATATCTGGGATATTGTTTGGATTAAGCAGCGCGGGATTGATTTATCCAAAGTATTGGTTGACAAGAAAC
TCACCGCCAGACACAAGCAAACAGATGACTTTCGACAGGCGCTGTCTACTGCCTTAGCCAAGCTAATGACGGAAGAGGAA
GTGCGAAATGACTTTAATATGGAAATAAGCCGCTTTATTCCTAAGCAAATTAAAGAGAGAACCCTAGATAGCCCAGAATA
TTGGACGTATGTTCAGGGAGAGGTGAATGCCATCGTATCTGAGTTACTTCATGATGGCACACCCAAAAAACCATTTGATA
TGGGTTAG

Antitoxin


Download         Length: 175 a.a.        Molecular weight: 19235.49 Da        Isoelectric Point: 9.8613

>AT61422 WP_062384553.1 NZ_CP014544:c4018581-4018057 [Zhongshania aliphaticivorans]
MTKSEELLSALAKAVNAGGGIHSATELAFMLGVPCGPAFRKFLADSVKKGLLRRVVKGFYESMITPPEPETAIYKIIKKL
RSGVLSYISLESQLSHTGDLSQIVIGRVTVVTKGRSGCFDTPYGVIEFTHTKKPVEQIAPNLYYDPAIKMYRAHKEQAIA
DLKHCRRNLHMLES

Download         Length: 525 bp

>AT61422 NZ_CP014544:c4018581-4018057 [Zhongshania aliphaticivorans]
ATGACGAAATCTGAGGAGCTATTAAGCGCGTTAGCCAAAGCGGTGAATGCTGGTGGTGGCATTCACAGTGCAACAGAGCT
TGCTTTTATGCTGGGTGTGCCTTGTGGCCCAGCTTTTAGAAAGTTCCTCGCAGATAGCGTAAAGAAGGGCTTGCTAAGGC
GAGTGGTGAAAGGCTTTTATGAAAGTATGATTACACCGCCAGAGCCAGAGACGGCCATTTATAAAATCATCAAAAAGTTG
CGTAGTGGCGTGTTGAGCTACATCAGCTTAGAAAGTCAGCTAAGCCATACCGGCGATCTTTCACAAATTGTGATAGGCAG
AGTCACTGTAGTCACTAAAGGCCGAAGTGGTTGTTTTGATACACCCTATGGTGTGATCGAATTTACCCACACTAAGAAGC
CAGTCGAACAAATCGCACCTAATTTGTACTATGACCCTGCCATCAAAATGTATCGCGCGCATAAAGAACAAGCAATTGCA
GATCTAAAGCACTGCCGACGCAATCTACATATGCTGGAGAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127MA18

Antitoxin

Source ID Structure
AlphaFold DB A0A127M9Z3

References