Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1654130..1654742 Replicon chromosome
Accession NZ_CP014542
Organism Streptococcus pyogenes strain STAB14018

Toxin (Protein)


Gene name parE Uniprot ID Q1JEY4
Locus tag AYM92_RS08720 Protein ID WP_020905490.1
Coordinates 1654407..1654742 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag AYM92_RS08715 Protein ID WP_002988079.1
Coordinates 1654130..1654417 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM92_RS08690 1649311..1650294 - 984 WP_020905487.1 tagatose-bisphosphate aldolase -
AYM92_RS08695 1650298..1651227 - 930 WP_076639463.1 tagatose-6-phosphate kinase -
AYM92_RS08700 1651273..1651788 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
AYM92_RS08705 1651823..1652251 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
AYM92_RS08710 1652696..1653469 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
AYM92_RS08715 1654130..1654417 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
AYM92_RS08720 1654407..1654742 + 336 WP_020905490.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AYM92_RS10050 1654894..1655364 + 471 Protein_1612 tyrosine-type recombinase/integrase family protein -
AYM92_RS10055 1655726..1655827 + 102 WP_180372495.1 hypothetical protein -
AYM92_RS08740 1655995..1656387 - 393 WP_002982716.1 30S ribosomal protein S9 -
AYM92_RS08745 1656408..1656854 - 447 WP_002982710.1 50S ribosomal protein L13 -
AYM92_RS08750 1657072..1657278 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
AYM92_RS08755 1657275..1657973 - 699 WP_161237464.1 hypothetical protein -
AYM92_RS08760 1658109..1658969 - 861 WP_002982687.1 DegV family protein -
AYM92_RS08765 1659066..1659584 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13147.98 Da        Isoelectric Point: 4.9405

>T61417 WP_020905490.1 NZ_CP014542:1654407-1654742 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIILYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T61417 NZ_CP014542:1654407-1654742 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCTTTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT61417 WP_002988079.1 NZ_CP014542:1654130-1654417 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT61417 NZ_CP014542:1654130-1654417 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q1JEY4

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References