Detailed information of TA system TA061415

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3402519..3403172
• Replicon: chromosome
• Accession: NZ_CP014540
• Organism: Acinetobacter baumannii strain XH857

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A9E9PBS3
• Locus tag: AYR69_RS16155
• Protein ID: WP_002096593.1
• Coordinates: 3402519..3402908 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: AYR69_RS16160
• Protein ID: WP_001288210.1
• Coordinates: 3402915..3403172 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYR69_RS16140	3397637..3399832	-	2196	WP_001158905.1	TRAP transporter large permease subunit	-
AYR69_RS16145	3400020..3400586	-	567	WP_000651536.1	rhombosortase	-
AYR69_RS16150	3400664..3401749	-	1086	WP_000049106.1	hypothetical protein	-
AYR69_RS16155	3402519..3402908	-	390	WP_002096593.1	hypothetical protein	Toxin
AYR69_RS16160	3402915..3403172	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
AYR69_RS16165	3403360..3404532	+	1173	WP_001190548.1	acyl-CoA dehydrogenase family protein	-
AYR69_RS16170	3404581..3406071	-	1491	WP_004745487.1	NAD(P)/FAD-dependent oxidoreductase	-
AYR69_RS16175	3406253..3406630	-	378	WP_001216380.1	50S ribosomal protein L17	-
AYR69_RS16180	3406649..3407656	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15677.99 Da
• Isoelectric Point: 10.3890

>T61415 WP_002096593.1 NZ_CP014540:c3402908-3402519 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T61415 NZ_CP014540:c3402908-3402519 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCACGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGTAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT61415 WP_001288210.1 NZ_CP014540:c3403172-3402915 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT61415 NZ_CP014540:c3403172-3402915 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7