Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2774643..2775294 Replicon chromosome
Accession NZ_CP014539
Organism Acinetobacter baumannii strain XH859

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag AYR68_RS13155 Protein ID WP_000838146.1
Coordinates 2775112..2775294 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag AYR68_RS13150 Protein ID WP_000966689.1
Coordinates 2774643..2775047 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYR68_RS13135 2769676..2770017 - 342 WP_001281459.1 phage tail protein -
AYR68_RS13140 2770135..2774100 - 3966 WP_000191304.1 tape measure protein -
AYR68_RS13145 2774161..2774562 - 402 WP_000720591.1 hypothetical protein -
AYR68_RS13150 2774643..2775047 - 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AYR68_RS13155 2775112..2775294 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
AYR68_RS13160 2775626..2776159 - 534 WP_001185622.1 hypothetical protein -
AYR68_RS13165 2776204..2777133 - 930 WP_000094300.1 hypothetical protein -
AYR68_RS13170 2777241..2777453 - 213 WP_000121166.1 hypothetical protein -
AYR68_RS13175 2777455..2777853 - 399 WP_001132270.1 hypothetical protein -
AYR68_RS13180 2777855..2778223 - 369 WP_000539752.1 hypothetical protein -
AYR68_RS13185 2778195..2778599 - 405 WP_000248324.1 hypothetical protein -
AYR68_RS13190 2778608..2778976 - 369 WP_000524231.1 hypothetical protein -
AYR68_RS13195 2778978..2779367 - 390 WP_000008492.1 hypothetical protein -
AYR68_RS13200 2779372..2780037 - 666 WP_000767881.1 stress-responsive nuclear envelope protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2751072..2805687 54615


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T61413 WP_000838146.1 NZ_CP014539:c2775294-2775112 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T61413 NZ_CP014539:c2775294-2775112 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT61413 WP_000966689.1 NZ_CP014539:c2775047-2774643 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT61413 NZ_CP014539:c2775047-2774643 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References