Detailed information of TA system TA061404

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2472914..2473593
• Replicon: chromosome
• Accession: NZ_CP014528
• Organism: Acinetobacter baumannii strain XH858

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: AZE33_RS11820
• Protein ID: WP_000838146.1
• Coordinates: 2473411..2473593 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: AZE33_RS11815
• Protein ID: WP_000966688.1
• Coordinates: 2472914..2473318 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AZE33_RS11805	2471870..2472133	-	264	WP_001275792.1	hypothetical protein	-
AZE33_RS11810	2472135..2472815	-	681	WP_000721572.1	hypothetical protein	-
AZE33_RS11815	2472914..2473318	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AZE33_RS11820	2473411..2473593	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
AZE33_RS11825	2473919..2474434	-	516	WP_038346477.1	hypothetical protein	-
AZE33_RS11830	2474504..2475421	-	918	WP_038346476.1	hypothetical protein	-
AZE33_RS11835	2475518..2476660	-	1143	WP_038348069.1	hypothetical protein	-
AZE33_RS11840	2476660..2477013	-	354	WP_015451444.1	hypothetical protein	-
AZE33_RS11845	2477082..2477525	-	444	WP_016654267.1	hypothetical protein	-
AZE33_RS11850	2477482..2477850	-	369	WP_020752909.1	hypothetical protein	-
AZE33_RS11855	2477822..2478232	-	411	WP_005124464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2466751..2488145	21394

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T61404 WP_000838146.1 NZ_CP014528:c2473593-2473411 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T61404 NZ_CP014528:c2473593-2473411 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT61404 WP_000966688.1 NZ_CP014528:c2473318-2472914 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT61404 NZ_CP014528:c2473318-2472914 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6