Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1321317..1321837 Replicon chromosome
Accession NZ_CP014518
Organism Sinomonas atrocyanea strain KCTC 3377

Toxin (Protein)


Gene name parE Uniprot ID A0A126ZZG0
Locus tag SA2016_RS06220 Protein ID WP_066496660.1
Coordinates 1321317..1321607 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A126ZZY2
Locus tag SA2016_RS06225 Protein ID WP_066496675.1
Coordinates 1321604..1321837 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA2016_RS21365 1316926..1317375 + 450 WP_141305686.1 DUF3761 domain-containing protein -
SA2016_RS06210 1317457..1318125 - 669 WP_066496654.1 hypothetical protein -
SA2016_RS06215 1318494..1321298 + 2805 WP_066496657.1 AAA family ATPase -
SA2016_RS06220 1321317..1321607 - 291 WP_066496660.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SA2016_RS06225 1321604..1321837 - 234 WP_066496675.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
SA2016_RS06230 1321896..1322657 - 762 WP_066496689.1 IclR family transcriptional regulator -
SA2016_RS06235 1322702..1324024 - 1323 WP_169803054.1 MFS transporter -
SA2016_RS06240 1324057..1324470 - 414 WP_066496691.1 cupin domain-containing protein -
SA2016_RS21370 1324600..1325529 + 930 WP_066496692.1 hypothetical protein -
SA2016_RS21375 1325529..1326296 + 768 WP_066496695.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(1-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11164.60 Da        Isoelectric Point: 7.2748

>T61371 WP_066496660.1 NZ_CP014518:c1321607-1321317 [Sinomonas atrocyanea]
VKQYRLTPAAVQDLSSIWDYTADRWGLGQAEIYVGELRGAIERVADRPDRGRPCDEIRAGYRRYAIGSHLIFYVETDTTV
DVIRILHQRMDPTRHF

Download         Length: 291 bp

>T61371 NZ_CP014518:c1321607-1321317 [Sinomonas atrocyanea]
GTGAAGCAGTACCGGCTCACGCCGGCCGCGGTACAGGACCTCTCATCCATCTGGGACTACACAGCCGACCGCTGGGGTCT
CGGCCAGGCCGAGATCTACGTAGGAGAGCTGCGCGGCGCCATCGAACGGGTCGCGGACCGCCCCGATCGCGGCCGCCCCT
GCGACGAGATCCGCGCCGGGTACCGGCGCTACGCGATCGGCAGCCACCTGATCTTCTACGTCGAGACCGATACGACGGTC
GACGTGATCCGCATCCTGCACCAACGCATGGACCCCACCCGGCACTTCTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8252.14 Da        Isoelectric Point: 4.7318

>AT61371 WP_066496675.1 NZ_CP014518:c1321837-1321604 [Sinomonas atrocyanea]
MARNTSISLDAHFSDFLAHEVATGRYGSASEVVRAGLRLLEDQEARLSALRSALSAGEASGEPEPFDFDAFIAAKRP

Download         Length: 234 bp

>AT61371 NZ_CP014518:c1321837-1321604 [Sinomonas atrocyanea]
ATGGCGCGCAATACGTCGATCAGCCTGGATGCCCACTTCTCCGATTTCCTCGCCCACGAGGTCGCGACGGGCCGCTACGG
GTCCGCGAGCGAGGTTGTCCGTGCCGGCCTCCGGCTTCTGGAGGATCAGGAGGCCCGACTCTCCGCGCTGCGCTCAGCCC
TGAGCGCGGGCGAGGCCAGCGGCGAGCCGGAACCCTTCGACTTCGACGCGTTCATCGCCGCGAAGCGCCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126ZZG0

Antitoxin

Source ID Structure
AlphaFold DB A0A126ZZY2

References