61370

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 2413993..2414495 Replicon chromosome
Accession NZ_CP014517
Organism Variovorax sp. PAMC 28711 strain PAMC28711

Toxin (Protein)


Gene name yoeB Uniprot ID A0A126ZEX1
Locus tag AX767_RS11835 Protein ID WP_068631527.1
Coordinates 2413993..2414247 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A126ZDE3
Locus tag AX767_RS11840 Protein ID WP_068631528.1
Coordinates 2414244..2414495 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AX767_RS11820 2409053..2410534 - 1482 WP_068631524.1 glycogen synthase GlgA -
AX767_RS11825 2410534..2411862 - 1329 WP_068631525.1 glucose-1-phosphate adenylyltransferase -
AX767_RS11830 2411919..2413979 - 2061 WP_068631526.1 glycogen debranching protein GlgX -
AX767_RS11835 2413993..2414247 - 255 WP_068631527.1 Txe/YoeB family addiction module toxin Toxin
AX767_RS11840 2414244..2414495 - 252 WP_068631528.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AX767_RS11845 2414573..2416744 - 2172 WP_068631529.1 1,4-alpha-glucan branching protein GlgB -
AX767_RS11850 2416956..2418209 + 1254 WP_156481033.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2193860..2440644 246784


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9945.45 Da        Isoelectric Point: 9.3589

>T61370 WP_068631527.1 NZ_CP014517:c2414247-2413993 [Variovorax sp. PAMC 28711]
VKLIFADEAWDDYLSWQKQDRKMVERINKLIAEVTRDPFAGVGKPEPLKHALAGYWSRRINDEHRMVYKIEGGSLLLAQL
RYHY

Download         Length: 255 bp

>T61370 NZ_CP014517:c2414247-2413993 [Variovorax sp. PAMC 28711]
GTGAAGTTGATCTTCGCCGACGAAGCGTGGGACGACTACCTCTCTTGGCAGAAGCAGGACCGGAAGATGGTCGAACGAAT
CAACAAGCTGATTGCCGAAGTCACGCGCGATCCGTTCGCCGGCGTGGGCAAGCCTGAACCGTTGAAGCATGCGCTGGCGG
GCTACTGGTCCAGGCGCATCAACGACGAGCACCGGATGGTCTACAAGATCGAGGGGGGCTCGCTGCTGCTGGCGCAGCTT
CGATACCACTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9240.47 Da        Isoelectric Point: 5.8208

>AT61370 WP_068631528.1 NZ_CP014517:c2414495-2414244 [Variovorax sp. PAMC 28711]
MDAITYSSARANLARTMDRVCEDHEALIITRNGEQAVVMLSLDDYQALEETAYLLRNPSNAKRLLSATSQLNEGKGVERK
LAK

Download         Length: 252 bp

>AT61370 NZ_CP014517:c2414495-2414244 [Variovorax sp. PAMC 28711]
ATGGATGCCATCACCTACTCATCCGCTCGTGCGAACCTGGCTCGCACGATGGACCGTGTGTGCGAAGACCACGAGGCCTT
GATCATCACCCGCAACGGCGAGCAGGCGGTGGTGATGCTTTCGCTGGACGACTACCAGGCCCTGGAAGAGACGGCGTACT
TGTTGCGCAACCCCTCGAACGCCAAGCGGCTGCTTTCTGCGACCTCCCAATTGAACGAAGGCAAGGGCGTGGAGCGAAAG
CTTGCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126ZEX1

Antitoxin

Source ID Structure
AlphaFold DB A0A126ZDE3

References