Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 3540524..3541110 Replicon chromosome
Accession NZ_CP014513
Organism Frondihabitans sp. PAMC 28766 strain SR6

Toxin (Protein)


Gene name mazF Uniprot ID A0A126Z563
Locus tag AX769_RS16955 Protein ID WP_066281754.1
Coordinates 3540763..3541110 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A126Z2V1
Locus tag AX769_RS16950 Protein ID WP_066281752.1
Coordinates 3540524..3540769 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AX769_RS16930 3536762..3537061 - 300 WP_066281741.1 DUF1905 domain-containing protein -
AX769_RS16935 3537071..3538027 - 957 WP_066281743.1 amidohydrolase -
AX769_RS16940 3538098..3538889 - 792 WP_066281746.1 IclR family transcriptional regulator -
AX769_RS16945 3539267..3540448 + 1182 WP_204249395.1 amidohydrolase family protein -
AX769_RS16950 3540524..3540769 + 246 WP_066281752.1 CopG family transcriptional regulator Antitoxin
AX769_RS16955 3540763..3541110 + 348 WP_066281754.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AX769_RS16960 3541132..3541332 + 201 WP_066281756.1 hypothetical protein -
AX769_RS16965 3541364..3542278 - 915 WP_066281757.1 hypothetical protein -
AX769_RS16970 3542374..3543483 - 1110 WP_066281758.1 hypothetical protein -
AX769_RS16975 3543636..3544289 + 654 WP_066281759.1 dihydrofolate reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12022.85 Da        Isoelectric Point: 4.6816

>T61369 WP_066281754.1 NZ_CP014513:3540763-3541110 [Frondihabitans sp. PAMC 28766]
VVIAHGDVVWVDFGSPRGSEPAKVRPAVVAQENWLLATDIATVLVVPLTSNTALEAFPGNVLVPIEASGLERDSVAVVSQ
IGPVSREYLDPYPVGHLPSYIVSKVAAGVRLVAGI

Download         Length: 348 bp

>T61369 NZ_CP014513:3540763-3541110 [Frondihabitans sp. PAMC 28766]
GTGGTAATCGCCCACGGCGACGTGGTCTGGGTGGACTTCGGTTCACCGCGAGGTTCGGAGCCCGCGAAGGTCCGCCCGGC
GGTCGTCGCGCAAGAGAACTGGCTGCTGGCCACCGACATCGCCACCGTCCTGGTCGTGCCGCTGACGTCGAACACGGCGC
TCGAGGCGTTTCCCGGCAATGTGCTGGTGCCGATCGAGGCGTCGGGGCTAGAGAGAGACTCGGTGGCAGTCGTCTCGCAG
ATCGGCCCCGTGAGCCGTGAGTACCTCGACCCGTACCCGGTCGGGCATCTGCCGTCGTACATCGTCTCGAAAGTGGCTGC
GGGCGTGCGCCTCGTCGCCGGCATCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9112.06 Da        Isoelectric Point: 4.8228

>AT61369 WP_066281752.1 NZ_CP014513:3540524-3540769 [Frondihabitans sp. PAMC 28766]
MRTAISLPDGDFERFERVAARNHMNRSEFYRLAADKLARELEGDAELTAQANAAIARAGQPSEDSAFLRASEQNLLRSTE
W

Download         Length: 246 bp

>AT61369 NZ_CP014513:3540524-3540769 [Frondihabitans sp. PAMC 28766]
ATGAGAACTGCTATCTCGCTTCCGGACGGCGACTTCGAGCGCTTCGAGCGTGTCGCGGCCCGCAACCACATGAACCGCTC
GGAGTTCTACCGGCTGGCGGCGGACAAGCTGGCCCGCGAGCTCGAAGGCGACGCCGAGCTCACCGCGCAGGCCAACGCCG
CCATCGCACGGGCCGGACAACCGTCGGAAGACAGCGCTTTTCTCCGCGCGTCAGAGCAGAACCTCCTTCGAAGCACGGAG
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126Z563

Antitoxin

Source ID Structure
AlphaFold DB A0A126Z2V1

References