61365

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2659436..2659910 Replicon chromosome
Accession NZ_CP014505
Organism Burkholderia sp. PAMC 28687

Toxin (Protein)


Gene name pasB Uniprot ID A0A242N2V5
Locus tag AX768_RS12265 Protein ID WP_062000967.1
Coordinates 2659436..2659705 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A242N220
Locus tag AX768_RS12270 Protein ID WP_062000184.1
Coordinates 2659689..2659910 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AX768_RS12240 2654858..2656501 - 1644 WP_062000181.1 chaperonin GroEL -
AX768_RS12245 2656609..2656899 - 291 WP_031362728.1 co-chaperone GroES -
AX768_RS12250 2657538..2658204 + 667 Protein_2411 arsenical resistance protein ArsH -
AX768_RS32000 2658185..2658988 + 804 Protein_2412 MFS transporter -
AX768_RS12265 2659436..2659705 - 270 WP_062000967.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AX768_RS12270 2659689..2659910 - 222 WP_062000184.1 TraY domain-containing protein Antitoxin
AX768_RS12275 2660025..2660504 + 480 Protein_2415 IS5 family transposase -
AX768_RS12285 2660844..2661871 - 1028 Protein_2416 IS110 family transposase -
AX768_RS12290 2661779..2662344 + 566 Protein_2417 GNAT family N-acetyltransferase -
AX768_RS12295 2662553..2663203 - 651 WP_062000186.1 hypothetical protein -
AX768_RS12300 2663605..2664588 + 984 WP_062000187.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2660844..2661653 809


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Relaxosome protein TraY

(4-48)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10407.14 Da        Isoelectric Point: 10.2157

>T61365 WP_062000967.1 NZ_CP014505:c2659705-2659436 [Burkholderia sp. PAMC 28687]
MVWRIEVSQTAEKQLAKLDRVVARGIVAFLRDRVSVINDPRAIGEALKGSELVEFWKYRVGDWRLICQIEDAHITITVLR
LGNRREIYR

Download         Length: 270 bp

>T61365 NZ_CP014505:c2659705-2659436 [Burkholderia sp. PAMC 28687]
TTGGTCTGGCGGATTGAGGTCTCACAAACCGCTGAAAAGCAGCTTGCAAAACTGGACCGCGTGGTCGCCCGGGGCATCGT
CGCGTTTCTGCGGGATCGGGTGTCGGTGATAAACGACCCGCGCGCGATCGGCGAGGCGCTCAAGGGCAGCGAACTGGTTG
AATTCTGGAAGTATCGCGTTGGTGACTGGCGGCTGATCTGCCAGATCGAGGACGCGCACATCACAATTACGGTGTTACGG
TTGGGCAACCGGCGTGAGATTTACCGCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8322.58 Da        Isoelectric Point: 5.8650

>AT61365 WP_062000184.1 NZ_CP014505:c2659910-2659689 [Burkholderia sp. PAMC 28687]
MLAIRLPEEIKARLETLAKRTGRSKTFYAREAILQHLDDLEDLYLAERAVKRIQAKEQTAGLDEVEARLGLAD

Download         Length: 222 bp

>AT61365 NZ_CP014505:c2659910-2659689 [Burkholderia sp. PAMC 28687]
ATGCTCGCCATCCGCCTGCCCGAAGAAATTAAAGCTCGCCTGGAGACGCTTGCCAAGCGCACCGGGCGCAGCAAGACGTT
CTATGCGCGTGAGGCCATTCTACAACACCTGGACGATCTGGAAGACCTCTATCTGGCTGAGCGGGCGGTTAAGCGTATCC
AGGCAAAGGAACAGACGGCTGGGCTGGATGAGGTGGAGGCACGGCTTGGTCTGGCGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A242N2V5

Antitoxin

Source ID Structure
AlphaFold DB A0A242N220

References