61364

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2349436..2350025 Replicon chromosome
Accession NZ_CP014505
Organism Burkholderia sp. PAMC 28687

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AX768_RS10920 Protein ID WP_061999970.1
Coordinates 2349633..2350025 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AX768_RS10915 Protein ID WP_061999969.1
Coordinates 2349436..2349636 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AX768_RS10890 2344437..2345417 - 981 WP_061999965.1 D-glycerate dehydrogenase -
AX768_RS10895 2345428..2346819 - 1392 WP_061999966.1 sodium:proton antiporter -
AX768_RS10900 2346994..2348184 - 1191 WP_061999967.1 nicotinate phosphoribosyltransferase -
AX768_RS10905 2348645..2348968 + 324 WP_061999968.1 ferredoxin family protein -
AX768_RS10915 2349436..2349636 + 201 WP_061999969.1 hypothetical protein Antitoxin
AX768_RS10920 2349633..2350025 + 393 WP_061999970.1 type II toxin-antitoxin system VapC family toxin Toxin
AX768_RS10925 2350129..2350872 + 744 WP_061999971.1 FadR family transcriptional regulator -
AX768_RS10930 2351132..2352049 + 918 WP_061999972.1 5-dehydro-4-deoxyglucarate dehydratase -
AX768_RS10935 2352128..2352715 - 588 WP_061999973.1 LUD domain-containing protein -
AX768_RS10940 2352712..2354121 - 1410 WP_061999974.1 lactate utilization protein -
AX768_RS10945 2354118..2354861 - 744 WP_061999975.1 (Fe-S)-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14379.21 Da        Isoelectric Point: 7.3160

>T61364 WP_061999970.1 NZ_CP014505:2349633-2350025 [Burkholderia sp. PAMC 28687]
VNYLLDTNAVIALMKGNGGFLARLRQHRPRDFAISSIVANGLYYGAYKSQNAAENLKRVEALQFEVLDFDTEDARHAGEV
RSQLALAGTSSGPYDALIAGQALARALTLVIRNTREFRHVSKLNVEDWES

Download         Length: 393 bp

>T61364 NZ_CP014505:2349633-2350025 [Burkholderia sp. PAMC 28687]
GTGAACTACTTGCTCGACACGAACGCCGTCATTGCGCTCATGAAGGGAAATGGCGGATTTCTCGCTCGGCTGCGACAGCA
TCGACCGCGCGATTTCGCTATCTCGTCCATCGTCGCAAACGGACTATATTACGGCGCATACAAGAGCCAGAACGCCGCCG
AGAACTTGAAGCGTGTTGAGGCGTTGCAATTCGAAGTTCTCGACTTCGATACTGAAGATGCCCGGCACGCAGGGGAAGTG
CGCTCGCAACTCGCGTTGGCCGGAACTTCAAGTGGACCGTATGACGCTCTCATCGCCGGACAGGCCCTTGCCCGCGCACT
CACACTTGTCATTCGAAATACCCGGGAGTTCCGTCACGTGAGCAAGCTGAACGTTGAGGACTGGGAAAGCTAG

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7835.77 Da        Isoelectric Point: 4.0813

>AT61364 WP_061999969.1 NZ_CP014505:2349436-2349636 [Burkholderia sp. PAMC 28687]
VRLPKEFRLDVDEVRVRRYGNAIILEPIANDWSWLEFIVGPVDEDFIQASTEQPTEQDRPDLDFFK

Download         Length: 201 bp

>AT61364 NZ_CP014505:2349436-2349636 [Burkholderia sp. PAMC 28687]
GTGCGCTTGCCCAAGGAGTTCCGACTGGACGTAGATGAAGTGCGTGTGCGGCGCTACGGCAACGCGATCATCCTCGAACC
GATCGCCAATGACTGGTCATGGCTCGAATTCATCGTCGGCCCCGTCGACGAAGACTTTATTCAGGCATCAACTGAGCAGC
CGACCGAACAGGACCGCCCAGATCTGGATTTCTTTAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References