Detailed information of TA system TA061349

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4942824..4943644
• Replicon: chromosome
• Accession: NZ_CP014497
• Organism: Escherichia coli strain ZH193

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: AVR69_RS24690
• Protein ID: WP_001054379.1
• Coordinates: 4943387..4943644 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: AVR69_RS24685
• Protein ID: WP_000123957.1
• Coordinates: 4942824..4943375 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AVR69_RS24660	4938518..4939831	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
AVR69_RS24665	4939843..4940121	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
AVR69_RS24670	4940118..4941239	-	1122	WP_000010833.1	M42 family metallopeptidase	-
AVR69_RS30290	4941484..4941600	-	117	Protein_4698	VOC family protein	-
AVR69_RS24675	4941638..4941898	-	261	WP_000077645.1	hypothetical protein	-
AVR69_RS24680	4942026..4942772	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
AVR69_RS24685	4942824..4943375	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
AVR69_RS24690	4943387..4943644	-	258	WP_001054379.1	YjhX family toxin	Toxin
AVR69_RS28200	4944021..4944185	-	165	Protein_4703	GNAT family N-acetyltransferase	-
AVR69_RS24705	4945428..4946534	+	1107	Protein_4705	helicase YjhR	-
AVR69_RS24710	4947117..4948097	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T61349 WP_001054379.1 NZ_CP014497:c4943644-4943387 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T61349 NZ_CP014497:c4943644-4943387 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT61349 WP_000123957.1 NZ_CP014497:c4943375-4942824 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT61349 NZ_CP014497:c4943375-4942824 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030