Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4738863..4739698 Replicon chromosome
Accession NZ_CP014495
Organism Escherichia coli strain SaT040

Toxin (Protein)


Gene name yeeV Uniprot ID S1PMM7
Locus tag AVR72_RS23690 Protein ID WP_000854720.1
Coordinates 4738863..4739240 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1P8X0
Locus tag AVR72_RS23695 Protein ID WP_001539669.1
Coordinates 4739330..4739698 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVR72_RS23660 4734131..4735669 - 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -
AVR72_RS23665 4736552..4736878 - 327 WP_000779482.1 type II toxin-antitoxin system RelE/ParE family toxin -
AVR72_RS23670 4736875..4737138 - 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
AVR72_RS23675 4737210..4738076 - 867 WP_001290180.1 DUF4942 domain-containing protein -
AVR72_RS23680 4738169..4738366 - 198 WP_000839238.1 DUF957 domain-containing protein -
AVR72_RS23685 4738378..4738866 - 489 WP_021535504.1 hypothetical protein -
AVR72_RS23690 4738863..4739240 - 378 WP_000854720.1 TA system toxin CbtA family protein Toxin
AVR72_RS23695 4739330..4739698 - 369 WP_001539669.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AVR72_RS23700 4739778..4739999 - 222 WP_000692349.1 DUF987 domain-containing protein -
AVR72_RS23705 4740086..4740562 - 477 WP_001186788.1 RadC family protein -
AVR72_RS23710 4740578..4741063 - 486 WP_000849596.1 antirestriction protein -
AVR72_RS23715 4741118..4741936 - 819 WP_001234642.1 DUF945 domain-containing protein -
AVR72_RS23720 4742036..4742269 - 234 WP_001119719.1 DUF905 family protein -
AVR72_RS23725 4742355..4742759 + 405 WP_001539664.1 IS66 family insertion sequence hypothetical protein -
AVR72_RS23730 4742756..4743103 + 348 WP_000612617.1 IS66 family insertion sequence element accessory protein TnpB -
AVR72_RS23735 4743152..4744690 + 1539 WP_061186101.1 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14089.02 Da        Isoelectric Point: 7.9087

>T61318 WP_000854720.1 NZ_CP014495:c4739240-4738863 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T61318 NZ_CP014495:c4739240-4738863 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13614.39 Da        Isoelectric Point: 5.9550

>AT61318 WP_001539669.1 NZ_CP014495:c4739698-4739330 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSN
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT61318 NZ_CP014495:c4739698-4739330 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCATGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAAT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FW05

Antitoxin

Source ID Structure
AlphaFold DB A0A829FYK7

References