Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 112768..113144 Replicon plasmid pG749_1
Accession NZ_CP014489
Organism Escherichia coli strain G749

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag AVR74_RS24890 Protein ID WP_001514250.1
Coordinates 112768..112950 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag AVR74_RS24895 Protein ID WP_001324224.1
Coordinates 112947..113144 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVR74_RS24880 110767..111801 - 1035 WP_001190234.1 3-deoxy-7-phosphoheptulonate synthase -
AVR74_RS24885 112361..112669 - 309 WP_000377483.1 hypothetical protein -
AVR74_RS24890 112768..112950 - 183 WP_001514250.1 hypothetical protein Toxin
AVR74_RS24895 112947..113144 - 198 WP_001324224.1 toxin-antitoxin system protein Antitoxin
AVR74_RS24900 113826..115100 + 1275 WP_000489608.1 HlyD family secretion protein -
AVR74_RS24905 115075..117189 + 2115 WP_001183604.1 peptidase domain-containing ABC transporter -
AVR74_RS24910 117359..117670 - 312 WP_001259758.1 colicin V -
AVR74_RS29120 117648..117884 - 237 WP_001323890.1 colicin V immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD / dfrA5 / blaTEM-1B / sul2 / aph(3'')-Ib / aph(6)-Id / aph(3')-Ia iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN 1..149732 149732


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6961.10 Da        Isoelectric Point: 4.5349

>T61291 WP_001514250.1 NZ_CP014489:c112950-112768 [Escherichia coli]
MMEIFWTMLTSQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV

Download         Length: 183 bp

>T61291 NZ_CP014489:c112950-112768 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGACCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7658.53 Da        Isoelectric Point: 7.2046

>AT61291 WP_001324224.1 NZ_CP014489:c113144-112947 [Escherichia coli]
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK

Download         Length: 198 bp

>AT61291 NZ_CP014489:c113144-112947 [Escherichia coli]
ATGGACCGTAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGA
CCAGGTTGAGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCAT
GGCGGGATGAAATGAGCAGGAAAGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References