6129

Detailed information of TA system    

experimentalExperimentally validated    

Overview


TA module


Type II Classification (family/domain) relBE/RHH-RelE
Location 3986..4592 Replicon plasmid pDC09
Accession NC_019238
Organism Streptococcus mutans

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HS723_RS00030 Protein ID WP_002290779.1
Coordinates 4254..4592 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HS723_RS00025 Protein ID WP_002290781.1
Coordinates 3977..4264 (+) Length 96 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS723_RS00005 (D683_p1) 397..1173 + 777 WP_002290776.1 hypothetical protein -
HS723_RS00010 (D683_p2) 1158..2825 + 1668 WP_002290775.1 type IV secretion system DNA-binding domain-containing protein -
HS723_RS00015 (D683_p3) 2838..3404 + 567 WP_002290773.1 hypothetical protein -
HS723_RS00020 (D683_p4) 3465..3782 + 318 WP_002290772.1 hypothetical protein -
HS723_RS00025 (D683_p5) 3977..4264 + 288 WP_002290781.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HS723_RS00030 (D683_p6) 4254..4592 + 339 WP_002290779.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - - 1..5637 5637


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 113 a.a.        Molecular weight: 13164.13 Da        Isoelectric Point: 7.0091

>T6129 WP_002290779.1 NC_019238:4254-4592 [Streptococcus mutans]
MNYKVKFTQPAIDDLDDIYSYYETELSKTSADKVMKSLREATNLLTFSPEGGIDFNKRIGQEVIQGQSLRMFVAQQYLIF
YIVVHSEVRIMRIISTKTNYMNELENLFKNFK

Download         Length: 339 bp

>T6129 NC_019238:4254-4592 [Streptococcus mutans]
ATGAATTATAAAGTGAAATTTACCCAGCCAGCTATTGATGATTTAGATGATATTTATAGTTATTATGAGACTGAACTTTC
AAAAACGTCTGCCGATAAAGTGATGAAAAGTCTAAGAGAAGCAACTAATTTATTAACTTTTTCACCAGAAGGCGGGATAG
ATTTCAATAAGAGAATTGGTCAAGAAGTTATTCAAGGACAGTCTCTTAGAATGTTTGTAGCTCAGCAATATCTCATATTC
TATATTGTAGTTCATTCAGAAGTCCGTATTATGCGAATTATCAGCACTAAAACAAACTATATGAACGAATTGGAAAATTT
ATTTAAGAATTTTAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11028.60 Da        Isoelectric Point: 4.4674

>AT6129 WP_002290781.1 NC_019238:3977-4264 [Streptococcus mutans]
MGTMLRNRQYNFRVNNDMLEQAKAVLEARNISIPDALNLFVETVVKEQDLPIKTIEERRAETFLAELTSELDKGYQAMLR
GEMKDADEVFAKYEL

Download         Length: 288 bp

>AT6129 NC_019238:3977-4264 [Streptococcus mutans]
ATGGGAACAATGTTGAGGAACAGACAATATAACTTTAGGGTTAATAATGATATGCTTGAACAAGCTAAAGCAGTCTTGGA
AGCTCGTAATATTAGCATACCAGATGCTCTAAATTTATTTGTAGAAACAGTCGTAAAAGAACAAGATTTGCCAATTAAAA
CAATAGAAGAACGTAGGGCAGAAACATTTTTAGCAGAATTAACGAGTGAACTTGATAAAGGTTATCAAGCTATGTTAAGA
GGCGAAATGAAGGATGCCGATGAGGTTTTTGCAAAGTATGAATTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
T6128 Streptococcus mutans

100

100

1


Multiple sequence alignment    


Protein Organism Identities (%) Coverage (%) Ha-value
AT6128 Streptococcus mutans

100

100

1


Multiple sequence alignment    




Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References


(1) Anke Rheinberg et al. (2013) Cryptic Streptococcus mutans 5.6-kb plasmids encode a toxin-antitoxin system for plasmid stabilization. Journal of Oral Microbiology 5:10.3402/jom.v5i0.19729. [PubMed:23330057] experimental


experimental experimental literature