Detailed information of TA system
Experimentally validatedOverview
TA module
Type | II | Classification (family/domain) | relBE/RHH-RelE |
Location | 3986..4592 | Replicon | plasmid pDC09 |
Accession | NC_019238 | ||
Organism | Streptococcus mutans |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | HS723_RS00030 | Protein ID | WP_002290779.1 |
Coordinates | 4254..4592 (+) | Length | 113 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | - |
Locus tag | HS723_RS00025 | Protein ID | WP_002290781.1 |
Coordinates | 3977..4264 (+) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HS723_RS00005 (D683_p1) | 397..1173 | + | 777 | WP_002290776.1 | hypothetical protein | - |
HS723_RS00010 (D683_p2) | 1158..2825 | + | 1668 | WP_002290775.1 | type IV secretion system DNA-binding domain-containing protein | - |
HS723_RS00015 (D683_p3) | 2838..3404 | + | 567 | WP_002290773.1 | hypothetical protein | - |
HS723_RS00020 (D683_p4) | 3465..3782 | + | 318 | WP_002290772.1 | hypothetical protein | - |
HS723_RS00025 (D683_p5) | 3977..4264 | + | 288 | WP_002290781.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
HS723_RS00030 (D683_p6) | 4254..4592 | + | 339 | WP_002290779.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Non-Mobilizable plasmid | - | - | 1..5637 | 5637 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 113 a.a. Molecular weight: 13164.13 Da Isoelectric Point: 7.0091
>T6129 WP_002290779.1 NC_019238:4254-4592 [Streptococcus mutans]
MNYKVKFTQPAIDDLDDIYSYYETELSKTSADKVMKSLREATNLLTFSPEGGIDFNKRIGQEVIQGQSLRMFVAQQYLIF
YIVVHSEVRIMRIISTKTNYMNELENLFKNFK
MNYKVKFTQPAIDDLDDIYSYYETELSKTSADKVMKSLREATNLLTFSPEGGIDFNKRIGQEVIQGQSLRMFVAQQYLIF
YIVVHSEVRIMRIISTKTNYMNELENLFKNFK
Download Length: 339 bp
>T6129 NC_019238:4254-4592 [Streptococcus mutans]
ATGAATTATAAAGTGAAATTTACCCAGCCAGCTATTGATGATTTAGATGATATTTATAGTTATTATGAGACTGAACTTTC
AAAAACGTCTGCCGATAAAGTGATGAAAAGTCTAAGAGAAGCAACTAATTTATTAACTTTTTCACCAGAAGGCGGGATAG
ATTTCAATAAGAGAATTGGTCAAGAAGTTATTCAAGGACAGTCTCTTAGAATGTTTGTAGCTCAGCAATATCTCATATTC
TATATTGTAGTTCATTCAGAAGTCCGTATTATGCGAATTATCAGCACTAAAACAAACTATATGAACGAATTGGAAAATTT
ATTTAAGAATTTTAAATAG
ATGAATTATAAAGTGAAATTTACCCAGCCAGCTATTGATGATTTAGATGATATTTATAGTTATTATGAGACTGAACTTTC
AAAAACGTCTGCCGATAAAGTGATGAAAAGTCTAAGAGAAGCAACTAATTTATTAACTTTTTCACCAGAAGGCGGGATAG
ATTTCAATAAGAGAATTGGTCAAGAAGTTATTCAAGGACAGTCTCTTAGAATGTTTGTAGCTCAGCAATATCTCATATTC
TATATTGTAGTTCATTCAGAAGTCCGTATTATGCGAATTATCAGCACTAAAACAAACTATATGAACGAATTGGAAAATTT
ATTTAAGAATTTTAAATAG
Antitoxin
Download Length: 96 a.a. Molecular weight: 11028.60 Da Isoelectric Point: 4.4674
>AT6129 WP_002290781.1 NC_019238:3977-4264 [Streptococcus mutans]
MGTMLRNRQYNFRVNNDMLEQAKAVLEARNISIPDALNLFVETVVKEQDLPIKTIEERRAETFLAELTSELDKGYQAMLR
GEMKDADEVFAKYEL
MGTMLRNRQYNFRVNNDMLEQAKAVLEARNISIPDALNLFVETVVKEQDLPIKTIEERRAETFLAELTSELDKGYQAMLR
GEMKDADEVFAKYEL
Download Length: 288 bp
>AT6129 NC_019238:3977-4264 [Streptococcus mutans]
ATGGGAACAATGTTGAGGAACAGACAATATAACTTTAGGGTTAATAATGATATGCTTGAACAAGCTAAAGCAGTCTTGGA
AGCTCGTAATATTAGCATACCAGATGCTCTAAATTTATTTGTAGAAACAGTCGTAAAAGAACAAGATTTGCCAATTAAAA
CAATAGAAGAACGTAGGGCAGAAACATTTTTAGCAGAATTAACGAGTGAACTTGATAAAGGTTATCAAGCTATGTTAAGA
GGCGAAATGAAGGATGCCGATGAGGTTTTTGCAAAGTATGAATTATAA
ATGGGAACAATGTTGAGGAACAGACAATATAACTTTAGGGTTAATAATGATATGCTTGAACAAGCTAAAGCAGTCTTGGA
AGCTCGTAATATTAGCATACCAGATGCTCTAAATTTATTTGTAGAAACAGTCGTAAAAGAACAAGATTTGCCAATTAAAA
CAATAGAAGAACGTAGGGCAGAAACATTTTTAGCAGAATTAACGAGTGAACTTGATAAAGGTTATCAAGCTATGTTAAGA
GGCGAAATGAAGGATGCCGATGAGGTTTTTGCAAAGTATGAATTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|---|---|---|---|
T6128 | Streptococcus mutans |
100 |
100 |
1 |
Multiple sequence alignment
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|---|---|---|---|
AT6128 | Streptococcus mutans |
100 |
100 |
1 |
Multiple sequence alignment
Structures
Toxin
Source | ID | Structure |
---|
Antitoxin
Source | ID | Structure |
---|
References
(1) Anke Rheinberg et al. (2013) Cryptic Streptococcus mutans 5.6-kb plasmids encode a toxin-antitoxin system for plasmid stabilization. Journal of Oral Microbiology 5:10.3402/jom.v5i0.19729. [PubMed:23330057]
experimental literature