Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 3636616..3637124 Replicon chromosome
Accession NZ_CP014476
Organism Methylomonas denitrificans strain FJG1

Toxin (Protein)


Gene name relE Uniprot ID A0A126T7R8
Locus tag JT25_RS16780 Protein ID WP_036278827.1
Coordinates 3636864..3637124 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A126T7P6
Locus tag JT25_RS16775 Protein ID WP_036278825.1
Coordinates 3636616..3636867 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT25_RS16745 3632189..3632620 - 432 WP_036278812.1 urease accessory protein UreE -
JT25_RS16750 3633057..3633413 + 357 WP_132324992.1 hypothetical protein -
JT25_RS16755 3633499..3634062 + 564 WP_132324995.1 hypothetical protein -
JT25_RS16760 3634157..3635860 - 1704 WP_036278819.1 urease subunit alpha -
JT25_RS16765 3635857..3636174 - 318 WP_036278821.1 urease subunit beta -
JT25_RS16770 3636184..3636486 - 303 WP_036278823.1 urease subunit gamma -
JT25_RS16775 3636616..3636867 + 252 WP_036278825.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JT25_RS16780 3636864..3637124 + 261 WP_036278827.1 Txe/YoeB family addiction module toxin Toxin
JT25_RS16785 3637526..3638239 - 714 WP_036275917.1 hypothetical protein -
JT25_RS16790 3638792..3639013 - 222 WP_064044745.1 hypothetical protein -
JT25_RS16795 3639038..3639889 - 852 WP_036275985.1 urease accessory protein UreD -
JT25_RS16800 3639909..3640214 - 306 WP_036275982.1 hypothetical protein -
JT25_RS16805 3640311..3641084 - 774 WP_036276007.1 ABC transporter ATP-binding protein -
JT25_RS16810 3641084..3641893 - 810 WP_052142261.1 urea ABC transporter ATP-binding protein UrtD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10238.73 Da        Isoelectric Point: 9.6408

>T61253 WP_036278827.1 NZ_CP014476:3636864-3637124 [Methylomonas denitrificans]
VKITFSSDAWDSYLYWQATDKAILKRINQLIKEIQRQPFEGIGKPEPLKHGLSGYWSRRINDEHRIVYKIAGDTLLIAQL
RFHYEY

Download         Length: 261 bp

>T61253 NZ_CP014476:3636864-3637124 [Methylomonas denitrificans]
GTGAAAATCACCTTTTCCTCCGACGCCTGGGACAGCTACCTCTACTGGCAAGCCACCGACAAAGCCATTCTTAAACGTAT
CAACCAACTGATCAAGGAAATCCAGCGCCAGCCATTCGAGGGCATCGGTAAGCCGGAACCTTTGAAACACGGTTTGTCCG
GCTATTGGTCGCGGCGGATAAACGACGAGCATCGGATCGTTTATAAGATTGCCGGCGATACGTTGTTGATTGCGCAGTTG
CGGTTTCACTATGAGTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9168.45 Da        Isoelectric Point: 4.4621

>AT61253 WP_036278825.1 NZ_CP014476:3636616-3636867 [Methylomonas denitrificans]
MDAISYSAARANLAKTMDKVCADHAPIIITRKSESPVVMLSLEDFQAMEETAYLLRSPANARRLLESIAELESGQGTERE
LIE

Download         Length: 252 bp

>AT61253 NZ_CP014476:3636616-3636867 [Methylomonas denitrificans]
ATGGACGCCATCAGTTACAGCGCCGCGCGCGCCAATTTGGCTAAAACCATGGACAAGGTTTGCGCCGACCATGCTCCCAT
CATCATCACCCGTAAAAGCGAATCCCCGGTAGTGATGCTGTCGTTGGAAGATTTCCAAGCCATGGAGGAAACCGCCTACC
TGCTACGTTCGCCCGCCAACGCCCGCCGCTTGCTGGAATCCATCGCCGAGCTGGAATCCGGCCAAGGCACGGAGCGCGAA
TTAATCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126T7R8

Antitoxin

Source ID Structure
AlphaFold DB A0A126T7P6

References