Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 2331018..2331540 Replicon chromosome
Accession NZ_CP014476
Organism Methylomonas denitrificans strain FJG1

Toxin (Protein)


Gene name relE Uniprot ID A0A126T4G2
Locus tag JT25_RS10740 Protein ID WP_036276141.1
Coordinates 2331271..2331540 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A126T4G6
Locus tag JT25_RS10735 Protein ID WP_036276143.1
Coordinates 2331018..2331290 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT25_RS10710 2326166..2327482 - 1317 WP_036276157.1 chromosomal replication initiator protein DnaA -
JT25_RS10715 2327604..2328218 + 615 WP_036276154.1 guanylate kinase -
JT25_RS10720 2328233..2328670 + 438 WP_036276151.1 hypothetical protein -
JT25_RS10725 2328800..2330080 + 1281 WP_036276148.1 glutamate-1-semialdehyde 2,1-aminomutase -
JT25_RS10730 2330049..2330645 + 597 WP_132325225.1 hypothetical protein -
JT25_RS10735 2331018..2331290 + 273 WP_036276143.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JT25_RS10740 2331271..2331540 + 270 WP_036276141.1 Txe/YoeB family addiction module toxin Toxin
JT25_RS10745 2331599..2332237 + 639 WP_052142270.1 hypothetical protein -
JT25_RS10750 2332283..2333608 + 1326 WP_036276177.1 DNA recombination protein RmuC -
JT25_RS10755 2334031..2334957 + 927 WP_036276139.1 hypothetical protein -
JT25_RS10760 2334999..2336066 + 1068 WP_062328567.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-64)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10525.16 Da        Isoelectric Point: 9.6413

>T61251 WP_036276141.1 NZ_CP014476:2331271-2331540 [Methylomonas denitrificans]
MKSLVFEGNTWAIYEELRDKDKVLHKALCKLLREMLRGDPASGLGKPEPLRHNLSGLWSRRISHKDRLIYKFDNNYIYIF
AIGGHYEQY

Download         Length: 270 bp

>T61251 NZ_CP014476:2331271-2331540 [Methylomonas denitrificans]
ATGAAATCGTTGGTATTTGAAGGTAACACGTGGGCGATATACGAAGAGCTAAGAGACAAAGACAAGGTTTTGCACAAAGC
GTTGTGCAAATTGCTCCGGGAAATGTTGCGTGGCGATCCTGCAAGCGGTTTGGGTAAACCGGAACCACTCAGGCATAATC
TTTCCGGCCTTTGGTCCAGGCGGATTTCCCACAAAGATCGGCTGATTTATAAGTTCGACAACAACTACATTTATATATTT
GCTATCGGCGGCCATTATGAACAGTATTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10141.19 Da        Isoelectric Point: 4.4328

>AT61251 WP_036276143.1 NZ_CP014476:2331018-2331290 [Methylomonas denitrificans]
VETVSVNQFRDNLKNYVEQVVDNHEPLKVTRRAGDAFVVISADDWEREQETLYVLQNAGLMAQISASTATHAQQKGYQPS
DEQLHEIVGI

Download         Length: 273 bp

>AT61251 NZ_CP014476:2331018-2331290 [Methylomonas denitrificans]
GTGGAAACCGTCAGCGTCAATCAATTCCGAGACAATTTAAAAAACTACGTCGAGCAAGTAGTCGATAACCACGAACCTTT
GAAAGTCACACGCCGAGCAGGTGATGCGTTTGTCGTGATCAGCGCGGACGATTGGGAACGGGAGCAGGAAACGCTTTATG
TTTTGCAAAACGCCGGCTTGATGGCGCAAATCAGCGCTTCCACCGCAACGCACGCTCAACAAAAAGGTTATCAACCCAGC
GACGAACAACTGCATGAAATCGTTGGTATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126T4G2

Antitoxin

Source ID Structure
AlphaFold DB A0A126T4G6

References