Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1418806..1419316 Replicon chromosome
Accession NZ_CP014476
Organism Methylomonas denitrificans strain FJG1

Toxin (Protein)


Gene name relE Uniprot ID A0A126T247
Locus tag JT25_RS06555 Protein ID WP_036274768.1
Coordinates 1418806..1419060 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A126T354
Locus tag JT25_RS06560 Protein ID WP_036274769.1
Coordinates 1419050..1419316 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT25_RS06540 1414107..1414781 + 675 WP_036274765.1 hypothetical protein -
JT25_RS06545 1414976..1418074 + 3099 WP_036274766.1 efflux RND transporter permease subunit -
JT25_RS06550 1418114..1418788 - 675 WP_036274767.1 hypothetical protein -
JT25_RS06555 1418806..1419060 - 255 WP_036274768.1 Txe/YoeB family addiction module toxin Toxin
JT25_RS06560 1419050..1419316 - 267 WP_036274769.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JT25_RS06565 1419382..1421817 - 2436 WP_062328020.1 carbamoyltransferase HypF -
JT25_RS06570 1421817..1422890 - 1074 WP_052142141.1 hydrogenase expression/formation protein HypE -
JT25_RS06575 1423114..1423371 + 258 WP_036274771.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10210.76 Da        Isoelectric Point: 7.2414

>T61250 WP_036274768.1 NZ_CP014476:c1419060-1418806 [Methylomonas denitrificans]
MPIKFADEAWEDYLYWQQTDKRMLKRINTLLKDIQRQPFEGLGKPEPLKHGLTGLWSRRIDEEHRLVYEMQDGCIAIVQC
RYHY

Download         Length: 255 bp

>T61250 NZ_CP014476:c1419060-1418806 [Methylomonas denitrificans]
ATGCCGATTAAGTTTGCCGACGAAGCTTGGGAAGATTATCTGTACTGGCAACAGACTGACAAGCGTATGTTGAAACGCAT
CAATACTTTGTTAAAAGACATTCAACGCCAACCATTCGAGGGTTTAGGCAAGCCCGAACCATTAAAGCATGGGCTGACGG
GGTTATGGTCGCGGCGGATCGACGAGGAGCATCGGTTGGTTTATGAAATGCAAGACGGCTGCATTGCTATAGTGCAGTGT
CGGTATCATTACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9919.13 Da        Isoelectric Point: 5.1133

>AT61250 WP_036274769.1 NZ_CP014476:c1419316-1419050 [Methylomonas denitrificans]
MDAINYSYTRQHFAEVMDKVNGDHAPILVTRQKGKPVVIISLDEYNSLEETAYLLRSPNNAKRLLSALEQVRKGGSQERS
LIEAEDAD

Download         Length: 267 bp

>AT61250 NZ_CP014476:c1419316-1419050 [Methylomonas denitrificans]
ATGGACGCAATCAATTACAGCTATACCCGTCAGCATTTTGCCGAAGTGATGGACAAGGTCAACGGCGATCACGCACCTAT
CCTGGTGACTCGGCAAAAAGGCAAACCGGTGGTGATTATCTCTCTAGATGAATACAACTCGCTGGAGGAAACCGCTTACT
TGCTGCGCAGCCCCAATAACGCCAAGCGCTTATTATCGGCGTTGGAGCAGGTGCGCAAAGGGGGCAGTCAGGAACGCAGC
CTGATTGAAGCCGAAGATGCCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126T247

Antitoxin

Source ID Structure
AlphaFold DB A0A126T354

References