Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 1162876..1163404 Replicon chromosome
Accession NZ_CP014476
Organism Methylomonas denitrificans strain FJG1

Toxin (Protein)


Gene name parE Uniprot ID A0A126T1G8
Locus tag JT25_RS05405 Protein ID WP_036275059.1
Coordinates 1163117..1163404 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A126T1H2
Locus tag JT25_RS05400 Protein ID WP_033159544.1
Coordinates 1162876..1163127 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT25_RS05365 1158048..1159130 + 1083 WP_062327862.1 tyrosine-type recombinase/integrase -
JT25_RS05370 1159487..1159747 + 261 WP_026603671.1 hypothetical protein -
JT25_RS05375 1159737..1160123 + 387 WP_036275060.1 type II toxin-antitoxin system VapC family toxin -
JT25_RS05380 1160507..1160977 + 471 WP_052142185.1 hypothetical protein -
JT25_RS05385 1161078..1161305 - 228 WP_062329812.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
JT25_RS05390 1161438..1161911 - 474 WP_062327865.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JT25_RS05395 1162037..1162546 - 510 WP_036275069.1 DUF1993 domain-containing protein -
JT25_RS05400 1162876..1163127 + 252 WP_033159544.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JT25_RS05405 1163117..1163404 + 288 WP_036275059.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JT25_RS23760 1163694..1163936 - 243 Protein_1074 type I restriction-modification system subunit M N-terminal domain-containing protein -
JT25_RS05410 1164214..1166745 - 2532 WP_082769145.1 DEAD/DEAH box helicase -
JT25_RS05415 1166754..1167644 - 891 WP_052142184.1 DUF1837 domain-containing protein -
JT25_RS24955 1168037..1168177 - 141 WP_157200639.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-90)

Antitoxin

Antitoxin ParD

(3-70)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11120.75 Da        Isoelectric Point: 6.3228

>T61249 WP_036275059.1 NZ_CP014476:1163117-1163404 [Methylomonas denitrificans]
MQIKKTVLADEDLVDIYLYGSQNFGQSQAERYFAEINQAFSFLAVNPWVANERPEFVPPARIHPHGKHLIVYTVEDDFLL
IVRVLHQRMDIKQHI

Download         Length: 288 bp

>T61249 NZ_CP014476:1163117-1163404 [Methylomonas denitrificans]
ATGCAAATTAAAAAAACGGTTCTTGCCGATGAAGACCTCGTCGACATCTACTTGTATGGCAGTCAAAACTTTGGACAATC
TCAAGCTGAAAGGTACTTTGCTGAAATCAATCAAGCATTTTCATTCTTAGCTGTCAATCCCTGGGTAGCAAACGAGCGCC
CAGAATTTGTGCCCCCTGCCCGTATTCATCCTCATGGCAAACATCTAATTGTTTACACTGTCGAAGACGACTTCCTGTTG
ATTGTTCGTGTTTTACACCAACGCATGGATATTAAACAGCACATCTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9396.49 Da        Isoelectric Point: 4.9803

>AT61249 WP_033159544.1 NZ_CP014476:1162876-1163127 [Methylomonas denitrificans]
MATMNISLPDPMRDWVQTQIQDGKYSSSSDYVRDLIRRDQETRQQQQVLQAAITEGLKSGISNRSMDDVLREAQARLAAL
NAN

Download         Length: 252 bp

>AT61249 NZ_CP014476:1162876-1163127 [Methylomonas denitrificans]
ATGGCAACTATGAATATTTCACTCCCCGACCCTATGCGTGATTGGGTTCAAACTCAGATTCAAGACGGCAAATACTCTAG
CAGCAGTGATTATGTGCGAGACCTGATACGCCGCGACCAAGAGACACGCCAACAACAGCAAGTCCTACAAGCCGCCATCA
CCGAAGGCTTAAAAAGCGGTATCAGCAACCGCTCAATGGATGATGTATTGAGAGAGGCCCAAGCGAGGCTGGCTGCTCTG
AATGCAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126T1G8

Antitoxin

Source ID Structure
AlphaFold DB A0A126T1H2

References