Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 1148269..1148807 Replicon chromosome
Accession NZ_CP014475
Organism Mycolicibacterium phlei strain CCUG 21000

Toxin (Protein)


Gene name relE Uniprot ID A0A5N5V777
Locus tag MPHLCCUG_RS05485 Protein ID WP_003887915.1
Coordinates 1148269..1148526 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5N5V726
Locus tag MPHLCCUG_RS05490 Protein ID WP_003887916.1
Coordinates 1148523..1148807 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPHLCCUG_RS05465 1143578..1144720 + 1143 WP_061482722.1 serine hydrolase -
MPHLCCUG_RS05470 1144812..1146419 - 1608 WP_061482721.1 peptide chain release factor 3 -
MPHLCCUG_RS05475 1146546..1146923 - 378 WP_003887913.1 hypothetical protein -
MPHLCCUG_RS05480 1146969..1148225 - 1257 WP_061482720.1 alpha/beta hydrolase -
MPHLCCUG_RS05485 1148269..1148526 - 258 WP_003887915.1 Txe/YoeB family addiction module toxin Toxin
MPHLCCUG_RS05490 1148523..1148807 - 285 WP_003887916.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MPHLCCUG_RS05495 1148886..1149443 - 558 WP_003887917.1 TetR/AcrR family transcriptional regulator -
MPHLCCUG_RS05500 1149554..1150300 + 747 WP_003887918.1 3-oxoacyl-ACP reductase FabG -
MPHLCCUG_RS05505 1150316..1150585 - 270 WP_061482719.1 hypothetical protein -
MPHLCCUG_RS05510 1150727..1151080 + 354 WP_003887920.1 hypothetical protein -
MPHLCCUG_RS05515 1151096..1151509 - 414 WP_061482718.1 DUF2628 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10378.73 Da        Isoelectric Point: 8.4840

>T61245 WP_003887915.1 NZ_CP014475:c1148526-1148269 [Mycolicibacterium phlei]
VRDIRFDPRAWEDFQFWLASDRKMARRIVRLISEIQRDPFDGIGKPEPLKGELSGYWSRRIDDEHRLVYRADDNEVKILQ
ARYHY

Download         Length: 258 bp

>T61245 NZ_CP014475:c1148526-1148269 [Mycolicibacterium phlei]
GTGAGGGATATCAGGTTCGATCCCCGGGCCTGGGAGGACTTCCAGTTCTGGTTGGCCTCCGACCGCAAGATGGCTCGACG
GATCGTCAGGCTCATCTCCGAGATTCAACGAGATCCGTTCGACGGAATCGGCAAGCCGGAACCGCTCAAAGGTGAACTCT
CCGGGTACTGGTCCCGTCGCATCGACGACGAACACCGCCTCGTCTATCGAGCCGACGACAACGAGGTCAAGATCCTGCAG
GCTCGATACCACTACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10510.65 Da        Isoelectric Point: 4.5822

>AT61245 WP_003887916.1 NZ_CP014475:c1148807-1148523 [Mycolicibacterium phlei]
VSISASEARRRLFPLLEQVNTDHEPVRITSRTGDAVLMSADDFDSWQETVYLLRSPENARRLMEAVARDKAAHGASPEPT
RSIDELREMAGGEE

Download         Length: 285 bp

>AT61245 NZ_CP014475:c1148807-1148523 [Mycolicibacterium phlei]
GTGAGCATCAGCGCCAGCGAGGCACGACGGCGTCTCTTTCCGCTGCTGGAACAGGTGAACACGGACCACGAGCCCGTTCG
CATCACCTCCAGGACGGGCGACGCGGTGCTCATGTCCGCGGACGACTTCGACTCGTGGCAGGAAACGGTCTACCTGCTGC
GTTCTCCCGAGAACGCCCGCCGACTCATGGAGGCTGTCGCGCGTGACAAAGCCGCACACGGCGCCTCCCCGGAACCGACC
AGGTCGATCGACGAGCTTCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5N5V777

Antitoxin

Source ID Structure
AlphaFold DB A0A5N5V726

References