Detailed information of TA system TA061234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2493527..2494200
• Replicon: chromosome
• Accession: NZ_CP014474
• Organism: Serratia rubidaea strain 1122

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: L0MGK3
• Locus tag: AXX16_RS11355
• Protein ID: WP_015672838.1
• Coordinates: 2493760..2494200 (+)
• Length: 147 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: AXX16_RS11350
• Protein ID: WP_061322939.1
• Coordinates: 2493527..2493763 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXX16_RS11325	2488710..2490314	+	1605	WP_061322930.1	Tar ligand binding domain-containing protein	-
AXX16_RS11330	2490343..2491203	+	861	WP_061322933.1	protein-glutamate O-methyltransferase CheR	-
AXX16_RS11335	2491203..2492252	+	1050	WP_061322936.1	chemotaxis response regulator protein-glutamate methylesterase	-
AXX16_RS11340	2492350..2492739	+	390	WP_054307799.1	chemotaxis response regulator CheY	-
AXX16_RS11345	2492752..2493396	+	645	WP_015672840.1	protein phosphatase CheZ	-
AXX16_RS11350	2493527..2493763	+	237	WP_061322939.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AXX16_RS11355	2493760..2494200	+	441	WP_015672838.1	type II toxin-antitoxin system VapC family toxin	Toxin
AXX16_RS11360	2494294..2495445	+	1152	WP_054307801.1	flagellar type III secretion system protein FlhB	-
AXX16_RS11365	2495438..2497519	+	2082	WP_054307802.1	flagellar biosynthesis protein FlhA	-
AXX16_RS11370	2497522..2497923	+	402	WP_061322943.1	flagellar protein FlhE	-
AXX16_RS11375	2498232..2499095	+	864	WP_015672834.1	protein deglycase HchA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-54)

Sequences

Toxin

Protein

• Length: 147 a.a.
• Molecular weight: 16276.71 Da
• Isoelectric Point: 9.8304

>T61234 WP_015672838.1 NZ_CP014474:2493760-2494200 [Serratia rubidaea]
MITHMLDTNIVIYVIKRRPREVLAVFNQHAGKMAISAVTYGELVHGVEKSARQVENLRVVEDFVSRLDVLPYTDKAAAHY
GNIRADLERKGTPIGVNDLHIAGHARSEGLVLVSNNLREFARIDGLRLENWLSSPIIPPSRPSSSK

Nucleotide

• Length: 441 bp

>T61234 NZ_CP014474:2493760-2494200 [Serratia rubidaea]
ATGATCACGCATATGCTGGATACCAATATTGTCATCTATGTGATCAAGCGTCGACCGCGCGAAGTGCTGGCGGTATTTAA
TCAGCACGCGGGAAAAATGGCGATATCTGCCGTGACCTATGGTGAGCTTGTGCACGGTGTGGAAAAGAGCGCCAGGCAGG
TTGAGAATCTGCGCGTCGTCGAGGATTTTGTTTCCCGGCTGGACGTTTTGCCCTACACCGACAAGGCGGCTGCTCACTAT
GGCAATATTCGCGCCGATCTTGAGCGTAAAGGCACGCCGATTGGGGTTAATGACCTGCATATCGCCGGCCATGCCCGCAG
TGAAGGCTTGGTATTGGTCAGCAATAATTTGCGCGAGTTTGCCCGCATCGACGGTCTGAGGCTGGAAAACTGGTTGTCAT
CACCAATCATTCCGCCATCTCGTCCCTCATCCTCGAAATAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8835.78 Da
• Isoelectric Point: 4.4013

>AT61234 WP_061322939.1 NZ_CP014474:2493527-2493763 [Serratia rubidaea]
MAIGSVFTNNRSQAVRLPAEARFPDSVSKVTVRVVGKERVLVPVENTWDSFFDQESLPGDDFLNERAAQYQAERESFE

Nucleotide

• Length: 237 bp

>AT61234 NZ_CP014474:2493527-2493763 [Serratia rubidaea]
ATGGCTATCGGTTCCGTTTTTACCAATAATCGCTCGCAGGCGGTACGTTTGCCGGCAGAGGCGCGTTTTCCTGATTCGGT
GTCGAAGGTGACGGTACGCGTGGTGGGTAAAGAGCGCGTTCTGGTCCCGGTGGAAAATACCTGGGACAGCTTTTTTGACC
AGGAGAGCCTGCCCGGTGATGATTTTCTGAATGAAAGAGCCGCGCAGTATCAGGCAGAGCGGGAAAGTTTTGAATGA

Structures

Toxin

• AlphaFold DB: A0A447QD36