Detailed information of TA system TA061233

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 2224594..2225237
• Replicon: chromosome
• Accession: NZ_CP014474
• Organism: Serratia rubidaea strain 1122

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: AXX16_RS10120
• Protein ID: WP_061322714.1
• Coordinates: 2224594..2225010 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A126VIW5
• Locus tag: AXX16_RS10125
• Protein ID: WP_061322715.1
• Coordinates: 2225007..2225237 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXX16_RS10105	2219793..2221448	-	1656	WP_061322712.1	BCCT family transporter	-
AXX16_RS10110	2221736..2223112	+	1377	WP_061322713.1	L-serine ammonia-lyase	-
AXX16_RS10115	2223393..2224547	+	1155	WP_054307158.1	GlxA family transcriptional regulator	-
AXX16_RS10120	2224594..2225010	-	417	WP_061322714.1	type II toxin-antitoxin system VapC family toxin	Toxin
AXX16_RS10125	2225007..2225237	-	231	WP_061322715.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AXX16_RS10130	2225553..2226530	+	978	WP_054307161.1	dipeptidase	-
AXX16_RS10135	2226562..2227092	+	531	WP_015673099.1	4-vinyl reductase	-
AXX16_RS10140	2227149..2229212	+	2064	WP_061322716.1	dimethylglycine demethylation protein DgcA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14986.30 Da
• Isoelectric Point: 7.8019

>T61233 WP_061322714.1 NZ_CP014474:c2225010-2224594 [Serratia rubidaea]
MSHTYMLDTCICSYIMREQPAAAIRRLEQAVMQRHRIVVSAITYAEMRFGAIGKKASPRHTQLVEAFCSRLDAILPWDRA
AVDETTTLKAALAAAGTPIGPNDTAIAGHAIATGAILVTNNYKEFARVPGLALEDWSA

Nucleotide

• Length: 417 bp

>T61233 NZ_CP014474:c2225010-2224594 [Serratia rubidaea]
ATGAGCCACACCTACATGCTGGACACCTGTATTTGCTCTTACATTATGCGCGAGCAGCCGGCAGCGGCGATCCGGCGTCT
GGAGCAGGCGGTGATGCAACGCCATCGGATCGTGGTGTCGGCCATTACCTATGCCGAAATGCGCTTTGGTGCGATCGGTA
AAAAGGCCTCACCGCGTCATACGCAGCTGGTCGAGGCCTTCTGCAGCCGCCTTGACGCCATTTTGCCGTGGGACCGCGCC
GCGGTGGATGAAACCACGACGCTGAAGGCCGCGTTGGCCGCCGCCGGTACGCCGATCGGGCCCAACGATACCGCAATTGC
CGGCCATGCCATCGCCACTGGCGCCATTCTGGTCACCAATAATTACAAGGAGTTTGCGCGCGTGCCCGGGCTGGCGCTGG
AGGACTGGTCGGCATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8677.83 Da
• Isoelectric Point: 4.6182

>AT61233 WP_061322715.1 NZ_CP014474:c2225237-2225007 [Serratia rubidaea]
MRTVSVFKNGNNRAIRLPRDMDFAGVNELEIAREGDTIILRPVKPSWGSFLLEDKADADFMTEREDIINDEGRVKP

Nucleotide

• Length: 231 bp

>AT61233 NZ_CP014474:c2225237-2225007 [Serratia rubidaea]
ATGAGAACAGTATCTGTGTTTAAAAACGGCAATAACCGCGCGATCCGCCTGCCCCGCGATATGGATTTTGCAGGCGTCAA
CGAACTGGAGATCGCCCGTGAAGGCGACACCATCATCCTGAGGCCGGTAAAGCCGAGCTGGGGATCGTTTCTGCTGGAAG
ACAAAGCCGATGCGGACTTTATGACGGAACGTGAAGACATCATTAATGACGAGGGACGCGTCAAACCATGA

Structures

Antitoxin

• AlphaFold DB: A0A126VIW5