Detailed information of TA system TA061232

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1559299..1559965
• Replicon: chromosome
• Accession: NZ_CP014474
• Organism: Serratia rubidaea strain 1122

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A4V6JI41
• Locus tag: AXX16_RS07170
• Protein ID: WP_054306177.1
• Coordinates: 1559546..1559965 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: AXX16_RS07165
• Protein ID: WP_061322415.1
• Coordinates: 1559299..1559565 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXX16_RS07140	1554419..1555738	+	1320	WP_061322412.1	MHS family MFS transporter	-
AXX16_RS07145	1555770..1556378	-	609	WP_061322413.1	HD domain-containing protein	-
AXX16_RS07150	1556573..1557253	+	681	WP_015673670.1	hemolysin III family protein	-
AXX16_RS07155	1557409..1557909	+	501	WP_061322414.1	DUF2165 domain-containing protein	-
AXX16_RS07160	1557970..1558959	-	990	WP_061325411.1	tRNA-modifying protein YgfZ	-
AXX16_RS07165	1559299..1559565	+	267	WP_061322415.1	FAD assembly factor SdhE	Antitoxin
AXX16_RS07170	1559546..1559965	+	420	WP_054306177.1	protein YgfX	Toxin
AXX16_RS07175	1559999..1560517	-	519	WP_041411867.1	flavodoxin FldB	-
AXX16_RS07180	1560609..1561508	+	900	WP_015673665.1	site-specific tyrosine recombinase XerD	-
AXX16_RS07185	1561536..1562252	+	717	WP_061322416.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
AXX16_RS07190	1562265..1563995	+	1731	WP_061325414.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 16292.19 Da
• Isoelectric Point: 11.2220

>T61232 WP_054306177.1 NZ_CP014474:1559546-1559965 [Serratia rubidaea]
VAQWRCDVRISWRTQLVSLLAHGALILLILISPWPESYDPIWLLLLTLVVFECIRSQTRIASRQGELRLLSAPQRVIWQG
KEWRLARRPWMLRGGMLLTLQASGKRKRRRLWLASDCISSAEWRQLCQRMQLAEDESEG

Nucleotide

• Length: 420 bp

>T61232 NZ_CP014474:1559546-1559965 [Serratia rubidaea]
GTGGCCCAGTGGCGATGTGATGTCCGCATCTCCTGGCGTACTCAGCTTGTTTCGCTGTTGGCGCATGGCGCGCTGATACT
GCTGATTCTGATCTCGCCGTGGCCGGAGAGTTACGACCCGATCTGGCTGTTGCTGCTGACGCTGGTGGTTTTCGAATGTA
TTCGCAGTCAGACGCGTATTGCTTCGCGTCAGGGGGAGCTGCGCCTGCTTTCCGCGCCGCAGCGGGTGATTTGGCAGGGC
AAGGAGTGGCGGCTGGCCCGTCGCCCCTGGATGCTGCGCGGCGGCATGCTGCTGACGCTGCAGGCGAGCGGCAAGCGCAA
ACGCCGCCGGCTGTGGCTGGCGTCGGACTGTATCAGCAGCGCCGAGTGGCGGCAGTTGTGCCAGCGGATGCAGCTGGCCG
AGGATGAGTCTGAAGGCTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10375.82 Da
• Isoelectric Point: 5.0843

>AT61232 WP_061322415.1 NZ_CP014474:1559299-1559565 [Serratia rubidaea]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEDKALFVRLLQSDDPDLFNWLMNHGAPQDAELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT61232 NZ_CP014474:1559299-1559565 [Serratia rubidaea]
ATGGATATTAATAATAAAGCGCGTATTCACTGGGCTTGCCGCCGGGGAATGCGTGAACTGGACATCTCCATCATGCCGTT
TTTTGAGCATGAGTACGATTCATTGAGCGACGAGGACAAGGCGCTGTTCGTGCGTCTGCTGCAGAGCGACGATCCCGATC
TGTTTAACTGGCTGATGAATCATGGCGCCCCGCAGGACGCCGAACTGCAGAGAATGGTGACGCTGATCCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: A0A4V6JI41