Detailed information of TA system TA061231

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 867164..867903
• Replicon: chromosome
• Accession: NZ_CP014474
• Organism: Serratia rubidaea strain 1122

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AXX16_RS03915
• Protein ID: WP_061321922.1
• Coordinates: 867164..867643 (-)
• Length: 160 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: L0MKT5
• Locus tag: AXX16_RS03920
• Protein ID: WP_015962211.1
• Coordinates: 867640..867903 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXX16_RS03900	864277..864750	-	474	WP_015962214.1	transcription elongation factor GreB	-
AXX16_RS03905	865041..865760	+	720	WP_004709363.1	two-component system response regulator OmpR	-
AXX16_RS03910	865757..867130	+	1374	WP_061321921.1	two-component system sensor histidine kinase EnvZ	-
AXX16_RS03915	867164..867643	-	480	WP_061321922.1	type II toxin-antitoxin system VapC family toxin	Toxin
AXX16_RS03920	867640..867903	-	264	WP_015962211.1	plasmid stability protein	Antitoxin
AXX16_RS03925	868028..869647	-	1620	WP_061321923.1	phosphoenolpyruvate carboxykinase (ATP)	-
AXX16_RS03930	869844..870725	-	882	WP_054305076.1	Hsp33 family molecular chaperone HslO	-
AXX16_RS03935	870751..871158	-	408	WP_015962208.1	ribosome-associated heat shock protein Hsp15	-
AXX16_RS03940	871155..871835	-	681	WP_015962207.1	GMP/IMP nucleotidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 160 a.a.
• Molecular weight: 17873.48 Da
• Isoelectric Point: 4.9342

>T61231 WP_061321922.1 NZ_CP014474:c867643-867164 [Serratia rubidaea]
MIILDTNVISETLRPKPHYNVISWLNEKDNSELYLSAIVVAELFSGVACMPDGKRQQALRLRLAEAIQINFDEQILPFDA
LCAMQYAELMGRNQRQGTPMSAPDAQIAATCLQYGATLATRNTKDFLHCGIELIDPWQVPAGQRLHEDAAEYYVMSRKS

Nucleotide

• Length: 480 bp

>T61231 NZ_CP014474:c867643-867164 [Serratia rubidaea]
ATGATTATTCTCGATACCAACGTGATCTCAGAAACGCTGCGCCCTAAACCGCATTACAACGTCATCAGTTGGCTGAACGA
AAAAGACAATAGCGAGCTGTACCTCAGCGCCATCGTCGTCGCCGAACTGTTTAGCGGCGTAGCCTGCATGCCGGACGGCA
AACGCCAGCAGGCGCTAAGGCTCAGGCTGGCGGAGGCGATTCAGATTAACTTTGATGAGCAGATTTTGCCGTTTGACGCC
CTGTGCGCCATGCAGTACGCGGAACTGATGGGCAGGAACCAGCGCCAGGGCACGCCGATGAGCGCGCCGGACGCGCAGAT
CGCCGCCACCTGTCTGCAGTACGGCGCCACGCTGGCCACGCGCAATACCAAAGATTTTCTCCATTGCGGCATCGAACTGA
TTGACCCCTGGCAGGTGCCTGCGGGGCAACGCCTGCATGAAGACGCGGCCGAATACTACGTGATGAGCCGGAAATCCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9834.22 Da
• Isoelectric Point: 5.6211

>AT61231 WP_015962211.1 NZ_CP014474:c867903-867640 [Serratia rubidaea]
MATITVRNLDDEVKELLRISAAKNGHSMEEEARMILKQALMKKPARYGLGSWMHQHFAEFGGVELAIPPRDAVPPRRVTF
DDDDDQA

Nucleotide

• Length: 264 bp

>AT61231 NZ_CP014474:c867903-867640 [Serratia rubidaea]
ATGGCTACCATTACCGTCAGAAATCTTGACGACGAAGTCAAAGAGCTGTTGCGTATTTCGGCAGCTAAAAATGGTCATTC
CATGGAAGAGGAGGCGCGGATGATCTTAAAACAGGCGCTGATGAAAAAGCCGGCGCGCTACGGGCTGGGCAGCTGGATGC
ATCAGCACTTCGCCGAATTCGGCGGCGTAGAACTGGCGATCCCGCCGCGCGATGCCGTGCCGCCGCGCCGTGTCACCTTC
GACGATGATGACGACCAGGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A126VDX2