61177

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 878794..879271 Replicon chromosome
Accession NZ_CP014438
Organism Staphylococcus aureus strain USA300-SUR22

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag AYM35_RS04460 Protein ID WP_000052078.1
Coordinates 878794..878982 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AYM35_RS04465 Protein ID WP_001059690.1
Coordinates 879011..879271 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM35_RS04430 874835..875305 + 471 WP_000824472.1 hypothetical protein -
AYM35_RS04435 875646..876332 + 687 WP_001548082.1 thermonuclease family protein -
AYM35_RS04440 876689..876889 + 201 WP_001059082.1 cold-shock protein -
AYM35_RS04445 877385..877603 - 219 WP_000005886.1 hypothetical protein -
AYM35_RS04450 877665..877949 - 285 WP_001004395.1 hypothetical protein -
AYM35_RS04455 878037..878606 - 570 WP_001106654.1 hypothetical protein -
AYM35_RS04460 878794..878982 - 189 WP_000052078.1 hypothetical protein Toxin
AYM35_RS04465 879011..879271 - 261 WP_001059690.1 hypothetical protein Antitoxin
AYM35_RS04470 879612..879815 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AYM35_RS04475 879812..880048 - 237 WP_000368687.1 hypothetical protein -
AYM35_RS04480 880273..880854 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
AYM35_RS04485 880927..881544 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
AYM35_RS04490 881699..882193 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AYM35_RS04495 882592..883014 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
AYM35_RS04500 883162..883878 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T61177 WP_000052078.1 NZ_CP014438:c878982-878794 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T61177 NZ_CP014438:c878982-878794 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT61177 WP_001059690.1 NZ_CP014438:c879271-879011 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT61177 NZ_CP014438:c879271-879011 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References