Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 883314..883791 Replicon chromosome
Accession NZ_CP014412
Organism Staphylococcus aureus strain USA300-SUR14

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag AYM27_RS04495 Protein ID WP_000052078.1
Coordinates 883314..883502 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AYM27_RS04500 Protein ID WP_001059690.1
Coordinates 883531..883791 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM27_RS04465 879355..879825 + 471 WP_000824472.1 hypothetical protein -
AYM27_RS04470 880166..880852 + 687 WP_001548082.1 thermonuclease family protein -
AYM27_RS04475 881209..881409 + 201 WP_001059082.1 cold-shock protein -
AYM27_RS04480 881905..882123 - 219 WP_000005886.1 hypothetical protein -
AYM27_RS04485 882185..882469 - 285 WP_001004395.1 hypothetical protein -
AYM27_RS04490 882557..883126 - 570 WP_001106654.1 hypothetical protein -
AYM27_RS04495 883314..883502 - 189 WP_000052078.1 hypothetical protein Toxin
AYM27_RS04500 883531..883791 - 261 WP_001059690.1 hypothetical protein Antitoxin
AYM27_RS04505 884132..884335 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AYM27_RS04510 884332..884568 - 237 WP_000368687.1 hypothetical protein -
AYM27_RS04515 884793..885374 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
AYM27_RS04520 885447..886064 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
AYM27_RS04525 886219..886713 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AYM27_RS04530 887112..887534 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
AYM27_RS04535 887682..888398 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T61033 WP_000052078.1 NZ_CP014412:c883502-883314 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T61033 NZ_CP014412:c883502-883314 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT61033 WP_001059690.1 NZ_CP014412:c883791-883531 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT61033 NZ_CP014412:c883791-883531 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References