Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Fic(toxin) |
| Location | 1365336..1365922 | Replicon | chromosome |
| Accession | NC_008596 | ||
| Organism | Mycobacterium smegmatis str. MC2 155 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A8B4QHV5 |
| Locus tag | MSMEG_RS06245 | Protein ID | WP_011727560.1 |
| Coordinates | 1365530..1365922 (+) | Length | 131 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A2U9PKT9 |
| Locus tag | MSMEG_RS06240 | Protein ID | WP_011727559.1 |
| Coordinates | 1365336..1365533 (+) | Length | 66 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MSMEG_RS06215 (MSMEG_1272) | 1360369..1361847 | - | 1479 | WP_011727554.1 | ADP-ribosylglycohydrolase family protein | - |
| MSMEG_RS06220 (MSMEG_1273) | 1362036..1362377 | - | 342 | WP_011727555.1 | DUF732 domain-containing protein | - |
| MSMEG_RS06225 (MSMEG_1274) | 1362437..1363564 | - | 1128 | WP_011727556.1 | SMP-30/gluconolactonase/LRE family protein | - |
| MSMEG_RS06230 (MSMEG_1275) | 1363745..1364824 | - | 1080 | WP_011727557.1 | HNH endonuclease | - |
| MSMEG_RS06235 (MSMEG_1276) | 1364892..1365188 | + | 297 | WP_011727558.1 | nucleoside triphosphate pyrophosphohydrolase | - |
| MSMEG_RS06240 (MSMEG_1277) | 1365336..1365533 | + | 198 | WP_011727559.1 | type II toxin-antitoxin system antitoxin Phd | Antitoxin |
| MSMEG_RS06245 (MSMEG_1278) | 1365530..1365922 | + | 393 | WP_011727560.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| MSMEG_RS06250 (MSMEG_1279) | 1365999..1367429 | + | 1431 | WP_003892661.1 | DUF3375 domain-containing protein | - |
| MSMEG_RS06255 (MSMEG_1280) | 1367426..1368001 | + | 576 | Protein_1244 | DUF4194 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 13939.57 Da Isoelectric Point: 4.2481
>T6093 WP_011727560.1 NC_008596:1365530-1365922 [Mycolicibacterium smegmatis MC2 155]
VTEYLDREDVLTAGSIAFGGELKVRDYGLLDAAVARPQATVYGVDAYPRLWDKAAALLQSLARNHALVDGNKRTAWAAAW
TFLHINGVQLAADFDVDRAEDLMNEVATRDCDLDSIAAELAGFAAAAQTG
VTEYLDREDVLTAGSIAFGGELKVRDYGLLDAAVARPQATVYGVDAYPRLWDKAAALLQSLARNHALVDGNKRTAWAAAW
TFLHINGVQLAADFDVDRAEDLMNEVATRDCDLDSIAAELAGFAAAAQTG
Download Length: 393 bp
>T6093 NC_008596:1365530-1365922 [Mycolicibacterium smegmatis MC2 155]
GTGACCGAGTACCTCGACCGCGAGGACGTGCTCACCGCGGGATCGATCGCTTTTGGCGGCGAGCTGAAGGTGCGGGACTA
CGGACTGCTCGACGCTGCGGTTGCCCGCCCGCAGGCCACGGTGTATGGCGTGGATGCGTACCCGCGGCTGTGGGACAAGG
CCGCTGCGTTGTTGCAGTCCCTGGCGCGGAACCATGCGCTGGTCGACGGTAACAAGCGCACTGCGTGGGCTGCGGCATGG
ACATTTCTGCACATCAACGGTGTACAGCTGGCGGCTGATTTCGATGTCGATCGCGCGGAGGACCTCATGAACGAGGTGGC
CACCCGTGACTGCGACCTGGATTCCATCGCCGCCGAGCTGGCCGGTTTCGCCGCTGCTGCGCAGACGGGGTGA
GTGACCGAGTACCTCGACCGCGAGGACGTGCTCACCGCGGGATCGATCGCTTTTGGCGGCGAGCTGAAGGTGCGGGACTA
CGGACTGCTCGACGCTGCGGTTGCCCGCCCGCAGGCCACGGTGTATGGCGTGGATGCGTACCCGCGGCTGTGGGACAAGG
CCGCTGCGTTGTTGCAGTCCCTGGCGCGGAACCATGCGCTGGTCGACGGTAACAAGCGCACTGCGTGGGCTGCGGCATGG
ACATTTCTGCACATCAACGGTGTACAGCTGGCGGCTGATTTCGATGTCGATCGCGCGGAGGACCTCATGAACGAGGTGGC
CACCCGTGACTGCGACCTGGATTCCATCGCCGCCGAGCTGGCCGGTTTCGCCGCTGCTGCGCAGACGGGGTGA
Antitoxin
Download Length: 66 a.a. Molecular weight: 7276.30 Da Isoelectric Point: 8.9353
>AT6093 WP_011727559.1 NC_008596:1365336-1365533 [Mycolicibacterium smegmatis MC2 155]
MPSLNIDFDEAEMEQIRAAARADDLSLKKFAHAAVMERASAHKRRVAEAARLVAERSAELNRRLA
MPSLNIDFDEAEMEQIRAAARADDLSLKKFAHAAVMERASAHKRRVAEAARLVAERSAELNRRLA
Download Length: 198 bp
>AT6093 NC_008596:1365336-1365533 [Mycolicibacterium smegmatis MC2 155]
ATGCCGTCGCTGAACATCGACTTCGACGAAGCCGAGATGGAACAGATCCGCGCTGCTGCCCGGGCGGATGACCTGTCGCT
GAAGAAGTTCGCGCACGCCGCCGTGATGGAGCGTGCCAGCGCGCACAAGCGCAGGGTCGCCGAGGCGGCGCGTCTGGTCG
CTGAGCGTTCGGCTGAGCTCAACCGCCGCTTGGCGTGA
ATGCCGTCGCTGAACATCGACTTCGACGAAGCCGAGATGGAACAGATCCGCGCTGCTGCCCGGGCGGATGACCTGTCGCT
GAAGAAGTTCGCGCACGCCGCCGTGATGGAGCGTGCCAGCGCGCACAAGCGCAGGGTCGCCGAGGCGGCGCGTCTGGTCG
CTGAGCGTTCGGCTGAGCTCAACCGCCGCTTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A8B4QHV5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2U9PKT9 |
References
(1) Rebekah Frampton et al. (2012) Toxin-antitoxin systems of Mycobacterium smegmatis are essential for cell survival. The Journal of Biological Chemistry 287(8):5340-56. [PubMed:22199354]