Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 883167..883644 Replicon chromosome
Accession NZ_CP014387
Organism Staphylococcus aureus strain USA300-SUR8

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag AYM21_RS04480 Protein ID WP_000052078.1
Coordinates 883167..883355 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AYM21_RS04485 Protein ID WP_001059690.1
Coordinates 883384..883644 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM21_RS04450 879208..879678 + 471 WP_000824472.1 hypothetical protein -
AYM21_RS04455 880019..880705 + 687 WP_001548082.1 thermonuclease family protein -
AYM21_RS04460 881062..881262 + 201 WP_001059082.1 cold-shock protein -
AYM21_RS04465 881758..881976 - 219 WP_000005886.1 hypothetical protein -
AYM21_RS04470 882038..882322 - 285 WP_001004395.1 hypothetical protein -
AYM21_RS04475 882410..882979 - 570 WP_001106654.1 hypothetical protein -
AYM21_RS04480 883167..883355 - 189 WP_000052078.1 hypothetical protein Toxin
AYM21_RS04485 883384..883644 - 261 WP_001059690.1 hypothetical protein Antitoxin
AYM21_RS04490 883985..884188 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AYM21_RS04495 884185..884421 - 237 WP_000368687.1 hypothetical protein -
AYM21_RS04500 884646..885227 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
AYM21_RS04505 885300..885917 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
AYM21_RS04510 886072..886566 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AYM21_RS04515 886965..887387 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
AYM21_RS04520 887535..888251 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T60927 WP_000052078.1 NZ_CP014387:c883355-883167 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T60927 NZ_CP014387:c883355-883167 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT60927 WP_001059690.1 NZ_CP014387:c883644-883384 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT60927 NZ_CP014387:c883644-883384 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References