60891

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 883074..883551 Replicon chromosome
Accession NZ_CP014381
Organism Staphylococcus aureus strain USA300-SUR6

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag AYM19_RS04465 Protein ID WP_000052078.1
Coordinates 883074..883262 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AYM19_RS04470 Protein ID WP_001059690.1
Coordinates 883291..883551 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM19_RS04435 879115..879585 + 471 WP_000824472.1 hypothetical protein -
AYM19_RS04440 879926..880612 + 687 WP_001548082.1 thermonuclease family protein -
AYM19_RS04445 880969..881169 + 201 WP_001059082.1 cold-shock protein -
AYM19_RS04450 881665..881883 - 219 WP_000005886.1 hypothetical protein -
AYM19_RS04455 881945..882229 - 285 WP_001004395.1 hypothetical protein -
AYM19_RS04460 882317..882886 - 570 WP_001106654.1 hypothetical protein -
AYM19_RS04465 883074..883262 - 189 WP_000052078.1 hypothetical protein Toxin
AYM19_RS04470 883291..883551 - 261 WP_001059690.1 hypothetical protein Antitoxin
AYM19_RS04475 883892..884095 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AYM19_RS04480 884092..884328 - 237 WP_000368687.1 hypothetical protein -
AYM19_RS04485 884553..885134 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
AYM19_RS04490 885207..885824 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
AYM19_RS04495 885979..886473 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AYM19_RS04500 886872..887294 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
AYM19_RS04505 887442..888158 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 877758..965621 87863


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-272)

Antitoxin

AbiEi antitoxin C-terminal domain

(84-237)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T60891 WP_000052078.1 NZ_CP014381:c883262-883074 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T60891 NZ_CP014381:c883262-883074 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT60891 WP_001059690.1 NZ_CP014381:c883551-883291 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT60891 NZ_CP014381:c883551-883291 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References