Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 872019..872496 Replicon chromosome
Accession NZ_CP014362
Organism Staphylococcus aureus strain USA300-SUR1

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag AYM13_RS04415 Protein ID WP_000052078.1
Coordinates 872019..872207 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AYM13_RS04420 Protein ID WP_001059690.1
Coordinates 872236..872496 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM13_RS04385 868060..868530 + 471 WP_000824472.1 hypothetical protein -
AYM13_RS04390 868871..869557 + 687 WP_001548082.1 thermonuclease family protein -
AYM13_RS04395 869914..870114 + 201 WP_001059082.1 cold-shock protein -
AYM13_RS04400 870610..870828 - 219 WP_000005886.1 hypothetical protein -
AYM13_RS04405 870890..871174 - 285 WP_001004395.1 hypothetical protein -
AYM13_RS04410 871262..871831 - 570 WP_001106654.1 hypothetical protein -
AYM13_RS04415 872019..872207 - 189 WP_000052078.1 hypothetical protein Toxin
AYM13_RS04420 872236..872496 - 261 WP_001059690.1 hypothetical protein Antitoxin
AYM13_RS04425 872837..873040 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AYM13_RS04430 873037..873273 - 237 WP_000368687.1 hypothetical protein -
AYM13_RS04435 873498..874079 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
AYM13_RS04440 874152..874769 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
AYM13_RS04445 874924..875418 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AYM13_RS04450 875817..876239 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
AYM13_RS04455 876387..877103 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 866703..897785 31082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(49-279)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(18-66)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T60801 WP_000052078.1 NZ_CP014362:c872207-872019 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T60801 NZ_CP014362:c872207-872019 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT60801 WP_001059690.1 NZ_CP014362:c872496-872236 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT60801 NZ_CP014362:c872496-872236 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References