Detailed information of TA system TA060797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3872210..3872799
• Replicon: chromosome
• Accession: NZ_CP014360
• Organism: Methylomonas sp. DH-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A172UBR4
• Locus tag: AYM39_RS17210
• Protein ID: WP_064022635.1
• Coordinates: 3872210..3872392 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A172UBV7
• Locus tag: AYM39_RS17215
• Protein ID: WP_064022636.1
• Coordinates: 3872389..3872799 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYM39_RS17180	3867567..3869384	-	1818	WP_064023587.1	ABC transporter ATP-binding protein/permease	-
AYM39_RS17190	3869829..3870083	+	255	WP_064022631.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
AYM39_RS17195	3870080..3870493	+	414	WP_064022632.1	type II toxin-antitoxin system VapC family toxin	-
AYM39_RS17200	3870967..3871200	+	234	WP_064022633.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
AYM39_RS17205	3871207..3871608	+	402	WP_064022634.1	type II toxin-antitoxin system VapC family toxin	-
AYM39_RS17210	3872210..3872392	+	183	WP_064022635.1	type II toxin-antitoxin system HicA family toxin	Toxin
AYM39_RS17215	3872389..3872799	+	411	WP_064022636.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AYM39_RS23990	3872827..3873105	+	279	WP_064022637.1	hypothetical protein	-
AYM39_RS23995	3873399..3873596	+	198	WP_157198227.1	hypothetical protein	-
AYM39_RS17225	3873627..3874817	+	1191	WP_064022638.1	reverse transcriptase family protein	-
AYM39_RS17230	3874819..3875028	+	210	WP_064022639.1	retron Se72 family effector protein	-
AYM39_RS17235	3875472..3875879	-	408	WP_064022640.1	type II toxin-antitoxin system VapC family toxin	-
AYM39_RS17240	3875885..3876142	-	258	WP_064022641.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
AYM39_RS17250	3876594..3877475	+	882	WP_064022643.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6644.76 Da
• Isoelectric Point: 11.4620

>T60797 WP_064022635.1 NZ_CP014360:3872210-3872392 [Methylomonas sp. DH-1]
MNSAELIKRLQNDGWLLRGVKGSHHVFTHPSKTGHISVPHPRKDLGQGLVNKLLKQAGLK

Nucleotide

• Length: 183 bp

>T60797 NZ_CP014360:3872210-3872392 [Methylomonas sp. DH-1]
ATGAATAGCGCGGAACTCATCAAGCGATTGCAAAACGATGGCTGGCTATTGCGGGGCGTAAAAGGATCGCATCACGTTTT
TACCCATCCATCCAAGACTGGGCACATCAGCGTGCCGCATCCGCGTAAGGACTTGGGCCAGGGACTGGTCAACAAACTAC
TGAAACAGGCAGGTTTGAAATGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14567.49 Da
• Isoelectric Point: 4.3103

>AT60797 WP_064022636.1 NZ_CP014360:3872389-3872799 [Methylomonas sp. DH-1]
MRYPIAIESGDETHAYGVVVPDLPGCFSAGDSLDEAIANAKEAIELWMETVIEDGEAIPEAAPIAKHQADPEFAGWIWAV
VEVDLSKLSGKAKRVNITLPERVLAAIDQAAARFGDTRSGLLAKAALEYVERHPAA

Nucleotide

• Length: 411 bp

>AT60797 NZ_CP014360:3872389-3872799 [Methylomonas sp. DH-1]
ATGAGATACCCGATAGCGATAGAAAGCGGCGACGAAACCCACGCCTACGGCGTCGTGGTGCCCGATTTGCCCGGTTGTTT
TTCCGCAGGCGACAGTTTGGACGAAGCGATAGCCAATGCCAAGGAGGCCATCGAACTATGGATGGAGACGGTCATCGAAG
ACGGCGAAGCCATTCCGGAAGCCGCGCCGATTGCCAAGCATCAGGCCGACCCGGAATTCGCCGGCTGGATTTGGGCGGTC
GTCGAAGTGGATCTGTCCAAACTGTCCGGCAAAGCCAAGCGGGTCAATATCACGCTGCCGGAACGGGTGCTGGCCGCCAT
CGACCAAGCCGCTGCGCGATTCGGCGATACCCGTTCCGGATTGCTGGCCAAAGCGGCTTTGGAATATGTCGAGAGGCATC
CGGCGGCTTGA

Structures

Toxin

• AlphaFold DB: A0A172UBR4

Antitoxin

• AlphaFold DB: A0A172UBV7