Detailed information of TA system TA060795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3869829..3870493
• Replicon: chromosome
• Accession: NZ_CP014360
• Organism: Methylomonas sp. DH-1

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: -
• Locus tag: AYM39_RS17195
• Protein ID: WP_064022632.1
• Coordinates: 3870080..3870493 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: A0A172UCR1
• Locus tag: AYM39_RS17190
• Protein ID: WP_064022631.1
• Coordinates: 3869829..3870083 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYM39_RS17175	3866368..3867321	-	954	WP_064022629.1	hypothetical protein	-
AYM39_RS17180	3867567..3869384	-	1818	WP_064023587.1	ABC transporter ATP-binding protein/permease	-
AYM39_RS17190	3869829..3870083	+	255	WP_064022631.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
AYM39_RS17195	3870080..3870493	+	414	WP_064022632.1	type II toxin-antitoxin system VapC family toxin	Toxin
AYM39_RS17200	3870967..3871200	+	234	WP_064022633.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
AYM39_RS17205	3871207..3871608	+	402	WP_064022634.1	type II toxin-antitoxin system VapC family toxin	-
AYM39_RS17210	3872210..3872392	+	183	WP_064022635.1	type II toxin-antitoxin system HicA family toxin	-
AYM39_RS17215	3872389..3872799	+	411	WP_064022636.1	type II toxin-antitoxin system HicB family antitoxin	-
AYM39_RS23990	3872827..3873105	+	279	WP_064022637.1	hypothetical protein	-
AYM39_RS23995	3873399..3873596	+	198	WP_157198227.1	hypothetical protein	-
AYM39_RS17225	3873627..3874817	+	1191	WP_064022638.1	reverse transcriptase family protein	-
AYM39_RS17230	3874819..3875028	+	210	WP_064022639.1	retron Se72 family effector protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-126)

Antitoxin

• SpoVT-AbrB domain (9-46)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15355.87 Da
• Isoelectric Point: 6.4588

>T60795 WP_064022632.1 NZ_CP014360:3870080-3870493 [Methylomonas sp. DH-1]
MIYMLDTNMLIYLIKNKPPSVAERINNLPENSALCMSFVTYAELLKGAEGSLRKEKVLAQLEQLLRIVPVEYAVGGALCR
YYASQFTRLKTAGTPIGANDLWIACHALAIGARLVTHNVREFERIEGLAVEDWADER

Nucleotide

• Length: 414 bp

>T60795 NZ_CP014360:3870080-3870493 [Methylomonas sp. DH-1]
ATGATCTATATGTTGGATACCAACATGTTGATCTATCTAATCAAAAACAAGCCGCCTTCTGTAGCCGAACGCATCAACAA
CCTCCCGGAGAATAGCGCGCTGTGCATGTCGTTCGTCACTTATGCCGAGTTGTTGAAGGGTGCTGAGGGCAGCCTACGCA
AGGAAAAAGTGTTGGCGCAGTTGGAACAATTGCTGCGGATCGTACCGGTCGAATATGCCGTTGGCGGTGCGTTATGTCGA
TACTACGCCAGCCAATTTACCCGGCTAAAAACGGCCGGAACGCCGATAGGCGCCAACGATTTGTGGATTGCCTGCCATGC
GCTGGCGATTGGCGCCCGCTTGGTCACGCATAACGTGCGGGAATTCGAGCGAATTGAGGGGTTGGCCGTCGAGGATTGGG
CGGATGAGCGGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9451.67 Da
• Isoelectric Point: 4.4000

>AT60795 WP_064022631.1 NZ_CP014360:3869829-3870083 [Methylomonas sp. DH-1]
MTTLTTRIFKNGNSQAVRIPQEFRLEVSQVEISRCPNGDLLIHPVPADRGAALLAVLQGFDDDFAEQLLENSREQVPMQE
RESL

Nucleotide

• Length: 255 bp

>AT60795 NZ_CP014360:3869829-3870083 [Methylomonas sp. DH-1]
ATGACGACTTTGACCACTCGCATTTTCAAAAACGGCAACAGCCAAGCGGTCAGAATTCCGCAGGAATTTCGGCTGGAGGT
TAGCCAAGTGGAAATCAGTCGTTGCCCCAATGGCGATTTGCTGATTCATCCGGTGCCGGCCGACCGGGGCGCGGCGTTGC
TGGCGGTTTTGCAAGGTTTCGACGACGACTTTGCCGAACAACTGCTCGAAAACTCCCGCGAGCAAGTCCCGATGCAGGAG
CGCGAGTCTTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A172UCR1