Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1609343..1609932 Replicon chromosome
Accession NZ_CP014360
Organism Methylomonas sp. DH-1

Toxin (Protein)


Gene name vapC Uniprot ID A0A172U6N6
Locus tag AYM39_RS07460 Protein ID WP_064021137.1
Coordinates 1609549..1609932 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A172U6T4
Locus tag AYM39_RS07455 Protein ID WP_064021136.1
Coordinates 1609343..1609552 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM39_RS07430 1605981..1606703 + 723 WP_064021131.1 pseudouridylate synthase -
AYM39_RS07435 1606713..1607108 - 396 WP_064021132.1 type II toxin-antitoxin system VapC family toxin -
AYM39_RS07440 1607105..1607371 - 267 WP_064021133.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
AYM39_RS24350 1607399..1607542 + 144 WP_172680328.1 hypothetical protein -
AYM39_RS07445 1607568..1608164 - 597 WP_064021134.1 Uma2 family endonuclease -
AYM39_RS07450 1608634..1609164 + 531 Protein_1513 transposase -
AYM39_RS07455 1609343..1609552 + 210 WP_064021136.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AYM39_RS07460 1609549..1609932 + 384 WP_064021137.1 type II toxin-antitoxin system VapC family toxin Toxin
AYM39_RS07465 1609975..1610349 + 375 Protein_1516 transposase -
AYM39_RS07470 1610469..1611623 - 1155 WP_064021138.1 TIR domain-containing protein -
AYM39_RS07475 1612607..1613713 + 1107 WP_064021139.1 3-isopropylmalate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14101.32 Da        Isoelectric Point: 5.6955

>T60792 WP_064021137.1 NZ_CP014360:1609549-1609932 [Methylomonas sp. DH-1]
MILVDTSVWVDHFKNRNEDLVRLLVSDSALIHPLIVAELACGTPPAPRTQTLNNLRQLRYCNQAGLQEVEDFIEREALYG
LGCGLIDLQLLASVLITPGAKLWTLDKRLAKLAERFGVAYQASPTTN

Download         Length: 384 bp

>T60792 NZ_CP014360:1609549-1609932 [Methylomonas sp. DH-1]
ATGATATTGGTCGATACCTCGGTTTGGGTTGACCATTTCAAAAATCGCAACGAAGACCTGGTGCGTTTGCTTGTTTCCGA
TTCGGCGTTGATTCACCCGCTGATCGTTGCCGAATTGGCTTGCGGTACGCCGCCCGCGCCGAGAACTCAAACCCTGAACA
ACCTGCGTCAGCTAAGGTATTGTAATCAAGCCGGTTTGCAGGAAGTGGAAGACTTTATCGAACGTGAAGCACTATATGGC
TTGGGTTGCGGGCTAATCGATTTGCAGTTGCTAGCCTCGGTTTTGATCACGCCCGGCGCCAAGCTGTGGACGTTGGACAA
GCGGTTGGCGAAACTTGCCGAGCGGTTTGGTGTGGCTTATCAAGCTTCGCCGACTACGAATTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7816.01 Da        Isoelectric Point: 5.0490

>AT60792 WP_064021136.1 NZ_CP014360:1609343-1609552 [Methylomonas sp. DH-1]
MRTTVTIDDTLYQKALEMADPDMDKAEIFREAMKTFVRIQAAKRLAALGGTMPEMADIPRDRRQTEPSA

Download         Length: 210 bp

>AT60792 NZ_CP014360:1609343-1609552 [Methylomonas sp. DH-1]
ATGAGAACCACCGTAACCATTGACGACACTTTGTATCAAAAAGCCCTGGAAATGGCCGATCCGGACATGGACAAGGCCGA
AATCTTCCGGGAAGCGATGAAAACCTTCGTGCGGATTCAGGCCGCTAAACGCTTGGCTGCGTTAGGTGGAACCATGCCGG
AGATGGCGGATATTCCCCGAGATCGCCGACAAACCGAACCGTCTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A172U6N6

Antitoxin

Source ID Structure
AlphaFold DB A0A172U6T4

References