Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1403295..1403803 Replicon chromosome
Accession NZ_CP014360
Organism Methylomonas sp. DH-1

Toxin (Protein)


Gene name relE Uniprot ID A0A172U674
Locus tag AYM39_RS06540 Protein ID WP_064020996.1
Coordinates 1403543..1403803 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A172U6C3
Locus tag AYM39_RS06535 Protein ID WP_054761862.1
Coordinates 1403295..1403546 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM39_RS06510 1399071..1400069 - 999 WP_157198290.1 IS5 family transposase -
AYM39_RS06515 1400222..1401925 - 1704 WP_064020992.1 urease subunit alpha -
AYM39_RS06520 1401922..1402239 - 318 WP_064020993.1 urease subunit beta -
AYM39_RS06525 1402302..1402799 - 498 WP_064020994.1 hypothetical protein -
AYM39_RS06530 1402859..1403161 - 303 WP_064020995.1 urease subunit gamma -
AYM39_RS06535 1403295..1403546 + 252 WP_054761862.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AYM39_RS06540 1403543..1403803 + 261 WP_064020996.1 Txe/YoeB family addiction module toxin Toxin
AYM39_RS23765 1404088..1404738 - 651 WP_157198109.1 hypothetical protein -
AYM39_RS06545 1405206..1405472 - 267 WP_082880827.1 type II toxin-antitoxin system RelE/ParE family toxin -
AYM39_RS06550 1405472..1405666 - 195 WP_197485129.1 hypothetical protein -
AYM39_RS06555 1405730..1406581 - 852 WP_064020999.1 urease accessory protein UreD -
AYM39_RS06560 1406594..1406899 - 306 WP_064021000.1 hypothetical protein -
AYM39_RS06565 1406994..1407767 - 774 WP_064021001.1 ABC transporter ATP-binding protein -
AYM39_RS06570 1407767..1408576 - 810 WP_064021002.1 urea ABC transporter ATP-binding protein UrtD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10240.71 Da        Isoelectric Point: 9.5752

>T60791 WP_064020996.1 NZ_CP014360:1403543-1403803 [Methylomonas sp. DH-1]
VKITFSSDAWDSYLYWQATDKAILKRINQLIKEIQRQPFEGIGKPEPLKHGLSGYWSRRINDEHRIVYKVAGDTLLIAQL
RYHYEY

Download         Length: 261 bp

>T60791 NZ_CP014360:1403543-1403803 [Methylomonas sp. DH-1]
GTGAAAATCACCTTTTCGTCCGACGCCTGGGACAGTTACCTGTACTGGCAAGCCACCGACAAAGCCATACTTAAACGCAT
CAACCAACTGATCAAGGAAATTCAGCGCCAACCCTTCGAAGGCATCGGCAAGCCGGAGCCCCTGAAACACGGTTTGTCCG
GCTATTGGTCGCGGCGGATTAACGACGAGCATAGGATCGTTTATAAGGTTGCCGGCGATACTTTGTTGATTGCGCAGTTG
CGGTATCACTATGAGTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9170.43 Da        Isoelectric Point: 4.4621

>AT60791 WP_054761862.1 NZ_CP014360:1403295-1403546 [Methylomonas sp. DH-1]
MDAISYSAARANLAKTMDKVCADHAPIIITRKSESPVVMLSLEDYQAMEETAYLLRSPANARRLLESIAELESGQGSERE
LIE

Download         Length: 252 bp

>AT60791 NZ_CP014360:1403295-1403546 [Methylomonas sp. DH-1]
ATGGACGCCATCAGTTACAGCGCCGCTCGCGCCAATTTAGCCAAAACCATGGACAAGGTTTGCGCCGACCATGCCCCCAT
CATCATCACCCGCAAAAGCGAGTCGCCGGTGGTGATGCTGTCGCTGGAAGACTACCAAGCCATGGAAGAAACCGCCTACC
TGCTGCGCTCGCCAGCCAACGCCCGCCGCTTGCTGGAATCCATTGCCGAATTGGAATCCGGCCAAGGCAGCGAGCGCGAG
TTGATCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A172U674

Antitoxin

Source ID Structure
AlphaFold DB A0A172U6C3

References