Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1139677..1140344 Replicon chromosome
Accession NZ_CP014360
Organism Methylomonas sp. DH-1

Toxin (Protein)


Gene name vapC Uniprot ID A0A172U5S7
Locus tag AYM39_RS05385 Protein ID WP_064020808.1
Coordinates 1139928..1140344 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A172U5M8
Locus tag AYM39_RS05380 Protein ID WP_064020807.1
Coordinates 1139677..1139931 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYM39_RS05365 1135144..1137303 + 2160 WP_157198091.1 EAL domain-containing protein -
AYM39_RS05370 1137406..1138362 + 957 WP_064020805.1 hypothetical protein -
AYM39_RS05375 1138350..1138979 - 630 WP_064020806.1 pyridoxamine 5'-phosphate oxidase family protein -
AYM39_RS05380 1139677..1139931 + 255 WP_064020807.1 hypothetical protein Antitoxin
AYM39_RS05385 1139928..1140344 + 417 WP_064020808.1 type II toxin-antitoxin system VapC family toxin Toxin
AYM39_RS05390 1140910..1141908 - 999 WP_157198285.1 IS5 family transposase -
AYM39_RS05395 1142077..1142778 + 702 WP_064020810.1 hypothetical protein -
AYM39_RS05400 1142794..1143546 + 753 WP_064020811.1 hypothetical protein -
AYM39_RS05405 1143788..1144276 - 489 WP_064020812.1 DUF2442 domain-containing protein -
AYM39_RS23710 1144273..1144476 - 204 WP_064020813.1 hypothetical protein -
AYM39_RS05415 1144691..1144942 + 252 WP_064020814.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14801.06 Da        Isoelectric Point: 4.8359

>T60790 WP_064020808.1 NZ_CP014360:1139928-1140344 [Methylomonas sp. DH-1]
MIVLDTNVISEAMRPEPHPAVLAWLNEQVAETLYLSTVTLAELLFGIAALPAGKRKDMLTKILEGLLQLFGDRVLPFDTD
AARQYAELAITARTGGRGFPTPDGYIAAIAASRGFAVASRDTAPYKAAGVSVINPWET

Download         Length: 417 bp

>T60790 NZ_CP014360:1139928-1140344 [Methylomonas sp. DH-1]
TTGATCGTCCTCGATACCAACGTCATTTCGGAAGCGATGAGGCCCGAGCCGCACCCGGCGGTGCTGGCTTGGCTGAATGA
ACAAGTTGCGGAAACACTGTACCTGTCCACCGTTACACTGGCCGAACTACTGTTTGGCATCGCCGCGCTGCCTGCGGGTA
AACGCAAAGACATGCTGACAAAAATCTTGGAGGGTTTATTGCAACTATTCGGGGACCGGGTGCTGCCTTTCGATACCGAC
GCAGCAAGGCAATATGCCGAGCTTGCCATCACAGCCAGGACGGGCGGACGAGGATTTCCAACGCCTGACGGCTATATCGC
CGCAATTGCCGCTTCACGCGGTTTCGCGGTGGCATCACGTGACACAGCGCCCTATAAAGCAGCCGGCGTGTCTGTCATCA
ATCCATGGGAAACATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9532.89 Da        Isoelectric Point: 4.7010

>AT60790 WP_064020807.1 NZ_CP014360:1139677-1139931 [Methylomonas sp. DH-1]
MAMLTVRNLPDDVHRALRVRAAQHGRSTEAEVREILTMSVKPEERVRMGEALMALGRQIGLTDEDVEVFEQMEDKAPADP
VRFD

Download         Length: 255 bp

>AT60790 NZ_CP014360:1139677-1139931 [Methylomonas sp. DH-1]
ATGGCAATGCTGACAGTACGTAATCTGCCCGACGACGTGCACCGAGCATTACGGGTGCGCGCCGCTCAACATGGGCGCAG
CACGGAAGCTGAGGTTCGCGAGATATTGACGATGAGCGTCAAGCCTGAAGAACGGGTTCGTATGGGTGAAGCGCTGATGG
CATTGGGTCGTCAGATCGGTTTAACCGACGAGGATGTCGAGGTATTCGAACAGATGGAAGACAAGGCTCCAGCCGACCCT
GTGAGGTTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A172U5S7

Antitoxin

Source ID Structure
AlphaFold DB A0A172U5M8

References