Detailed information of TA system TA060787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 20094..20619
• Replicon: plasmid pSO2_STV
• Accession: NZ_CP014357
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SO2 isolate SOHS 02-20

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: SE17cs_RS24020
• Protein ID: WP_001159863.1
• Coordinates: 20314..20619 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: SE17cs_RS24015
• Protein ID: WP_000813641.1
• Coordinates: 20094..20312 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SE17cs_RS23990	15381..15762	+	382	Protein_20	YgiW/YdeI family stress tolerance OB fold protein	-
SE17cs_RS26660	15931..16375	+	445	Protein_21	site-specific integrase	-
SE17cs_RS24000	16634..17623	-	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
SE17cs_RS26375	18117..18413	-	297	WP_001687482.1	hypothetical protein	-
SE17cs_RS24010	18897..19418	-	522	WP_010999942.1	hypothetical protein	-
SE17cs_RS24015	20094..20312	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
SE17cs_RS24020	20314..20619	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
SE17cs_RS24025	20621..20911	+	291	WP_001266176.1	hypothetical protein	-
SE17cs_RS24030	20908..21429	+	522	WP_000198608.1	hypothetical protein	-
SE17cs_RS24035	21464..22246	+	783	WP_000082169.1	site-specific integrase	-
SE17cs_RS24040	22255..22968	+	714	Protein_30	EAL domain-containing protein	-
SE17cs_RS24045	22972..23481	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
SE17cs_RS24050	23475..23960	+	486	WP_000905606.1	membrane protein	-
SE17cs_RS26665	24237..24524	-	288	WP_071530243.1	hypothetical protein	-
SE17cs_RS24060	24680..25240	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93837	93837

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (12-128)

Antitoxin

• Post-segregation antitoxin CcdA (19-61)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T60787 WP_001159863.1 NZ_CP014357:20314-20619 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T60787 NZ_CP014357:20314-20619 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT60787 WP_000813641.1 NZ_CP014357:20094-20312 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT60787 NZ_CP014357:20094-20312 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6