Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PHD(antitoxin) |
| Location | 2248535..2249217 | Replicon | chromosome |
| Accession | NZ_CP014352 | ||
| Organism | Acidipropionibacterium acidipropionici strain ATCC 55737 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | AXH35_RS10310 | Protein ID | WP_062819791.1 |
| Coordinates | 2248535..2248954 (-) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | K7SF30 |
| Locus tag | AXH35_RS10315 | Protein ID | WP_015068797.1 |
| Coordinates | 2248954..2249217 (-) | Length | 88 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AXH35_RS10265 | 2243538..2243921 | + | 384 | WP_015068789.1 | D-ribose pyranase | - |
| AXH35_RS10270 | 2243939..2244700 | - | 762 | WP_062819787.1 | ABC transporter permease | - |
| AXH35_RS10275 | 2244697..2245500 | - | 804 | WP_062819788.1 | ATP-binding cassette domain-containing protein | - |
| AXH35_RS10280 | 2245497..2245904 | - | 408 | WP_126133026.1 | DUF1048 domain-containing protein | - |
| AXH35_RS10285 | 2245904..2246221 | - | 318 | WP_198401494.1 | PadR family transcriptional regulator | - |
| AXH35_RS10290 | 2246383..2247300 | - | 918 | WP_082815990.1 | SDR family oxidoreductase | - |
| AXH35_RS10300 | 2247693..2248061 | + | 369 | WP_099093033.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| AXH35_RS10305 | 2248061..2248372 | + | 312 | WP_081685418.1 | helix-turn-helix domain-containing protein | - |
| AXH35_RS10310 | 2248535..2248954 | - | 420 | WP_062819791.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| AXH35_RS10315 | 2248954..2249217 | - | 264 | WP_015068797.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| AXH35_RS10320 | 2249339..2249605 | - | 267 | WP_015068798.1 | hypothetical protein | - |
| AXH35_RS10325 | 2249835..2250284 | + | 450 | WP_062819792.1 | CBS domain-containing protein | - |
| AXH35_RS10330 | 2250337..2251629 | + | 1293 | WP_062820775.1 | ArsB/NhaD family transporter | - |
| AXH35_RS10335 | 2251611..2252132 | - | 522 | WP_062819793.1 | MFS transporter | - |
| AXH35_RS10340 | 2252066..2252923 | - | 858 | WP_062819794.1 | MFS transporter | - |
| AXH35_RS10345 | 2253193..2254002 | - | 810 | WP_071001126.1 | tyrosine-protein phosphatase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15033.29 Da Isoelectric Point: 4.9147
>T60785 WP_062819791.1 NZ_CP014352:c2248954-2248535 [Acidipropionibacterium acidipropionici]
MFYADTSALVKLVVIEPESGALLDWLGHRDAALATSDLARTELVRSMRRRAPEAITQARDVLSRLLLVRADAQIFDEAAR
LMPPEVRSLDAVHLATALALGDDLEGVITYNLRMADAAHGLGLEVAAPGTPRNPQPNII
MFYADTSALVKLVVIEPESGALLDWLGHRDAALATSDLARTELVRSMRRRAPEAITQARDVLSRLLLVRADAQIFDEAAR
LMPPEVRSLDAVHLATALALGDDLEGVITYNLRMADAAHGLGLEVAAPGTPRNPQPNII
Download Length: 420 bp
>T60785 NZ_CP014352:c2248954-2248535 [Acidipropionibacterium acidipropionici]
ATGTTCTACGCGGACACCTCTGCACTGGTGAAACTCGTCGTCATCGAGCCGGAGTCCGGAGCCCTGCTGGACTGGCTCGG
ACACCGCGACGCCGCCCTGGCGACCAGCGACCTCGCCCGCACCGAGCTGGTGCGCTCCATGCGCCGCAGGGCTCCAGAGG
CCATCACGCAGGCCCGCGACGTGCTGTCACGACTGCTCCTGGTGAGGGCCGATGCCCAGATCTTCGACGAAGCCGCACGT
CTCATGCCGCCAGAGGTTCGAAGTCTCGACGCCGTGCATCTCGCCACGGCACTGGCACTGGGGGACGATCTCGAGGGAGT
CATCACCTACAACCTCCGGATGGCCGACGCCGCCCACGGCCTGGGGCTGGAGGTCGCCGCACCGGGGACACCACGAAACC
CCCAGCCAAACATCATTTGA
ATGTTCTACGCGGACACCTCTGCACTGGTGAAACTCGTCGTCATCGAGCCGGAGTCCGGAGCCCTGCTGGACTGGCTCGG
ACACCGCGACGCCGCCCTGGCGACCAGCGACCTCGCCCGCACCGAGCTGGTGCGCTCCATGCGCCGCAGGGCTCCAGAGG
CCATCACGCAGGCCCGCGACGTGCTGTCACGACTGCTCCTGGTGAGGGCCGATGCCCAGATCTTCGACGAAGCCGCACGT
CTCATGCCGCCAGAGGTTCGAAGTCTCGACGCCGTGCATCTCGCCACGGCACTGGCACTGGGGGACGATCTCGAGGGAGT
CATCACCTACAACCTCCGGATGGCCGACGCCGCCCACGGCCTGGGGCTGGAGGTCGCCGCACCGGGGACACCACGAAACC
CCCAGCCAAACATCATTTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9390.67 Da Isoelectric Point: 10.3568
>AT60785 WP_015068797.1 NZ_CP014352:c2249217-2248954 [Acidipropionibacterium acidipropionici]
MSEVGIRELKQNASSVVRRAAAGEEITVTDRGRPVARLSAIDHGGVRGLLAADRARPPIRALSDLPAPTIAADVSSVLRQ
MRDEERY
MSEVGIRELKQNASSVVRRAAAGEEITVTDRGRPVARLSAIDHGGVRGLLAADRARPPIRALSDLPAPTIAADVSSVLRQ
MRDEERY
Download Length: 264 bp
>AT60785 NZ_CP014352:c2249217-2248954 [Acidipropionibacterium acidipropionici]
ATGAGTGAGGTCGGCATCCGCGAGTTGAAGCAGAACGCCTCGAGCGTCGTCCGCCGGGCCGCCGCTGGCGAGGAGATCAC
GGTGACCGATCGGGGTCGGCCGGTCGCGCGACTCTCCGCCATCGATCACGGCGGAGTGCGCGGGCTGCTCGCCGCCGACC
GGGCCCGCCCACCGATCCGGGCACTGAGCGATCTCCCCGCGCCCACGATCGCCGCCGACGTCTCCTCGGTTCTCCGGCAG
ATGCGCGACGAGGAGCGCTACTGA
ATGAGTGAGGTCGGCATCCGCGAGTTGAAGCAGAACGCCTCGAGCGTCGTCCGCCGGGCCGCCGCTGGCGAGGAGATCAC
GGTGACCGATCGGGGTCGGCCGGTCGCGCGACTCTCCGCCATCGATCACGGCGGAGTGCGCGGGCTGCTCGCCGCCGACC
GGGCCCGCCCACCGATCCGGGCACTGAGCGATCTCCCCGCGCCCACGATCGCCGCCGACGTCTCCTCGGTTCTCCGGCAG
ATGCGCGACGAGGAGCGCTACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|