Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1425484..1426124 Replicon chromosome
Accession NZ_CP014352
Organism Acidipropionibacterium acidipropionici strain ATCC 55737

Toxin (Protein)


Gene name vapC Uniprot ID A0A3S5HP76
Locus tag AXH35_RS06760 Protein ID WP_062819382.1
Coordinates 1425732..1426124 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID K7S7C8
Locus tag AXH35_RS06755 Protein ID WP_015071399.1
Coordinates 1425484..1425735 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXH35_RS06740 1421420..1422352 + 933 WP_062819380.1 hydrogen peroxide-inducible genes activator -
AXH35_RS06745 1422455..1423888 - 1434 WP_062819381.1 adenylosuccinate lyase -
AXH35_RS06750 1423950..1425269 - 1320 WP_062820686.1 phosphoribosylamine--glycine ligase -
AXH35_RS06755 1425484..1425735 + 252 WP_015071399.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AXH35_RS06760 1425732..1426124 + 393 WP_062819382.1 type II toxin-antitoxin system VapC family toxin Toxin
AXH35_RS06765 1426326..1427612 - 1287 WP_015071401.1 adenylosuccinate synthase -
AXH35_RS06770 1427817..1428683 - 867 WP_015071402.1 GNAT family N-acetyltransferase -
AXH35_RS06775 1428744..1429445 - 702 WP_071001097.1 DUF3151 family protein -
AXH35_RS06780 1429597..1429887 + 291 WP_198401452.1 metal-sensitive transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-82)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13530.30 Da        Isoelectric Point: 4.0038

>T60782 WP_062819382.1 NZ_CP014352:1425732-1426124 [Acidipropionibacterium acidipropionici]
MIVDTSALVAVLTGEPDAEHLLDVMIGADRLALSAASLVEASVVLEARAGSEAVADLHALLADLDTEVLPCDETQAITAA
QAWSRFGKGRHPAALNLGDLFSYAAAITQGESLLFKGDAFPQTDIVVADR

Download         Length: 393 bp

>T60782 NZ_CP014352:1425732-1426124 [Acidipropionibacterium acidipropionici]
ATGATCGTCGACACGTCTGCCCTGGTGGCCGTACTCACAGGAGAGCCCGACGCCGAGCACCTGCTTGACGTCATGATCGG
CGCCGACCGCCTGGCATTGAGCGCCGCCAGCCTGGTTGAGGCTTCTGTCGTTCTCGAGGCACGCGCTGGATCCGAGGCGG
TGGCCGATCTTCACGCGCTACTGGCCGACCTCGACACGGAAGTCCTGCCGTGTGACGAGACCCAGGCGATCACAGCAGCT
CAGGCATGGAGCCGTTTCGGGAAGGGGCGTCACCCTGCTGCGCTGAACCTCGGCGACTTGTTCTCATATGCCGCCGCAAT
TACTCAGGGAGAGTCACTTCTCTTCAAGGGCGACGCCTTCCCACAAACCGACATCGTGGTAGCCGATCGGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9500.56 Da        Isoelectric Point: 6.0829

>AT60782 WP_015071399.1 NZ_CP014352:1425484-1425735 [Acidipropionibacterium acidipropionici]
MALNIKDPDTDRLARELAEETGETLTSALHAALAERLTRVRRQHRVSSRPDLHHYIERARARAVLDDRDADEIIGYDENG
LPR

Download         Length: 252 bp

>AT60782 NZ_CP014352:1425484-1425735 [Acidipropionibacterium acidipropionici]
ATGGCGCTCAACATCAAGGACCCGGACACCGACCGGCTGGCCCGTGAACTTGCAGAGGAGACCGGCGAGACCCTCACCTC
TGCGCTGCACGCCGCCCTGGCTGAACGCTTGACACGAGTGCGCCGTCAGCACCGGGTCTCCTCCCGGCCCGATCTGCATC
ACTACATCGAACGCGCGCGAGCCAGGGCCGTGCTCGATGATCGCGACGCCGACGAGATCATCGGCTATGACGAGAACGGC
CTGCCACGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5HP76

Antitoxin

Source ID Structure
AlphaFold DB K7S7C8

References