Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1117051..1118486 Replicon chromosome
Accession NZ_CP014346
Organism Mycoplasma mycoides subsp. mycoides strain T1/44

Toxin (Protein)


Gene name abiEii Uniprot ID Q6MU66
Locus tag MSCT144_RS05135 Protein ID WP_011166377.1
Coordinates 1117647..1118486 (+) Length 280 a.a.

Antitoxin (Protein)


Gene name abiEi Uniprot ID A0A7U5HSJ1
Locus tag MSCT144_RS05130 Protein ID WP_015545367.1
Coordinates 1117051..1117647 (+) Length 199 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MSCT144_RS05115 (MSCT144_10720) 1112175..1112669 + 495 WP_011166381.1 membrane protein -
MSCT144_RS05120 (MSCT144_10730) 1112741..1115431 + 2691 WP_011166380.1 alanine--tRNA ligase -
MSCT144_RS05125 (MSCT144_10740) 1115537..1116841 + 1305 WP_011166379.1 BspA family leucine-rich repeat surface protein -
MSCT144_RS05130 (MSCT144_10750) 1117051..1117647 + 597 WP_015545367.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
MSCT144_RS05135 (MSCT144_10760) 1117647..1118486 + 840 WP_011166377.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
MSCT144_RS05150 (MSCT144_10800) 1120006..1121611 - 1606 Protein_989 IS1634-like element IS1634 family transposase -
MSCT144_RS06695 (MSCT144_10810) 1121724..1121888 - 165 WP_015545676.1 hypothetical protein -
MSCT144_RS07495 (MSCT144_10820) 1121957..1122151 - 195 WP_011166373.1 hypothetical protein -
MSCT144_RS07500 (MSCT144_10830) 1122297..1122809 - 513 WP_015545636.1 hypothetical protein -
MSCT144_RS07505 (MSCT144_10840) 1122882..1123307 - 426 WP_011166371.1 transglutaminase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-257)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(6-53)


Sequences

Toxin        


Download         Length: 280 a.a.        Molecular weight: 33073.99 Da        Isoelectric Point: 9.7009

>T60750 WP_011166377.1 NZ_CP014346:1117647-1118486 [Mycoplasma mycoides subsp. mycoides]
MNLQKLKSICKRLSSETKTNYNIILKHYFMISILEKIVKSKNKQNFVIKGGFLLSNMMSLNERTTQDIDCLIKGINFVKE
NILRTISDVLRYDFTDFIKYEIKEITEIKKRDKYNGFRVKILCKLEKLEEIVKIDLAIGDVVTPSEIKYNFRNIFSNSSF
EIQAYNLETILAEKIFIINNLNIQSTRIKDLYDIFLIYSFKEFEIDYNILKCACLNTFKKRNTVFNIDLVLSLLNEINQL
DIFELLNNYRQKYFYAQKIEFKILIKSVIKFLEKLKNI

Download         Length: 840 bp

>T60750 NZ_CP014346:1117647-1118486 [Mycoplasma mycoides subsp. mycoides]
ATGAACTTACAGAAATTAAAATCAATTTGTAAAAGGTTATCAAGTGAAACAAAAACAAATTATAATATCATCTTAAAACA
TTACTTTATGATATCCATATTAGAAAAAATTGTTAAAAGTAAAAATAAACAAAACTTTGTAATTAAAGGTGGGTTCTTAC
TTTCTAATATGATGAGTTTAAACGAAAGAACCACTCAAGATATAGATTGCTTAATAAAAGGTATCAATTTTGTTAAAGAG
AATATTCTAAGAACTATTTCTGATGTATTAAGATATGATTTTACTGACTTTATAAAATATGAAATAAAAGAAATAACAGA
AATAAAAAAGAGAGACAAATATAATGGATTTAGAGTCAAAATATTATGCAAATTAGAAAAGTTGGAAGAAATAGTAAAAA
TAGATTTAGCAATTGGTGATGTTGTAACACCGTCTGAGATTAAATACAATTTTAGAAATATCTTTTCAAATAGTAGCTTT
GAAATACAAGCATATAATCTAGAAACAATATTAGCTGAAAAAATATTTATAATTAATAATTTAAATATACAATCAACTAG
AATAAAAGATCTTTATGATATTTTTTTAATATATAGCTTTAAAGAGTTTGAGATTGATTATAATATTCTAAAATGTGCTT
GTTTAAATACTTTTAAAAAAAGAAATACTGTTTTTAATATAGATTTAGTACTTAGTTTATTAAATGAAATTAACCAATTA
GATATTTTTGAATTACTTTGAAATAATTACAGGCAAAAATACTTTTACGCCCAAAAAATAGAATTTAAAATACTGATAAA
ATCTGTAATTAAGTTTTTAGAAAAGTTAAAAAATATTTAA

Antitoxin


Download         Length: 199 a.a.        Molecular weight: 23637.30 Da        Isoelectric Point: 9.3217

>AT60750 WP_015545367.1 NZ_CP014346:1117051-1117647 [Mycoplasma mycoides subsp. mycoides]
MNYKEQLIKEAKKRAGIITRKEIMNLKIPSIYITRMIRSNELEKVDIGIYALTSENWYYDPDYNFSIRHKTPIFSYTYAL
TFFDFTDVIPMFRDVTVYHGYNAHNLDPQTRVHYVSKDIYELGVVEVKTNCGNKIRAYDIERTICDFIKHRDKIEAELFA
KTMYKYSEYEKRDKKLHEYAKKMNIGKKVYEVFQVLV

Download         Length: 597 bp

>AT60750 NZ_CP014346:1117051-1117647 [Mycoplasma mycoides subsp. mycoides]
ATGAATTATAAAGAACAGCTGATAAAAGAAGCTAAAAAAAGAGCCGGTATTATTACAAGAAAAGAAATTATGAATTTAAA
AATTCCATCAATTTATATTACAAGAATGATTAGAAGTAATGAATTAGAAAAAGTCGATATTGGTATTTATGCTCTAACTT
CTGAAAATTGGTACTATGATCCTGATTATAATTTTAGTATCAGACATAAAACACCTATTTTTTCTTATACTTATGCACTT
ACATTTTTTGATTTTACAGATGTTATTCCAATGTTTCGTGATGTAACTGTTTATCATGGATATAATGCTCATAATTTAGA
CCCACAAACTAGAGTACACTATGTTTCAAAAGATATATATGAACTTGGAGTTGTAGAAGTAAAAACAAATTGTGGTAATA
AAATTAGAGCTTATGATATTGAAAGAACAATTTGTGATTTTATTAAGCATAGAGATAAAATCGAAGCTGAACTATTTGCA
AAAACTATGTATAAATATTCTGAATATGAAAAAAGAGATTGAAAAAAACTTCATGAATATGCTAAAAAAATGAACATTGG
TAAGAAAGTTTATGAAGTTTTTCAAGTATTAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q6MU66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U5HSJ1

References