Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | VII | Classification (family/domain) | HepT-MntA/HepT(toxin) |
Location | 2361300..2362104 | Replicon | chromosome |
Accession | NZ_CP014342 | ||
Organism | Geobacillus subterraneus strain KCTC3922(T) |
Toxin (Protein)
Gene name | hepT | Uniprot ID | A0A143MK67 |
Locus tag | GS3922_RS11585 | Protein ID | WP_063166496.1 |
Coordinates | 2361685..2362104 (+) | Length | 140 a.a. |
Antitoxin (Protein)
Gene name | mntA | Uniprot ID | A0A143MN77 |
Locus tag | GS3922_RS11580 | Protein ID | WP_063167397.1 |
Coordinates | 2361300..2361695 (+) | Length | 132 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GS3922_RS11535 | 2356600..2357082 | - | 483 | WP_020959115.1 | DUF111 family protein | - |
GS3922_RS11540 | 2357108..2358022 | - | 915 | WP_063166489.1 | LarC family nickel insertion protein | - |
GS3922_RS11545 | 2358028..2358777 | - | 750 | WP_063167396.1 | nickel pincer cofactor biosynthesis protein LarB | - |
GS3922_RS11550 | 2358782..2359051 | - | 270 | WP_063166490.1 | hypothetical protein | - |
GS3922_RS11555 | 2359199..2360002 | - | 804 | WP_063166491.1 | ATP-dependent sacrificial sulfur transferase LarE | - |
GS3922_RS11560 | 2360030..2360523 | - | 494 | Protein_2315 | SDR family oxidoreductase | - |
GS3922_RS11565 | 2360545..2360850 | - | 306 | WP_174539025.1 | hypothetical protein | - |
GS3922_RS11570 | 2360877..2361101 | - | 225 | Protein_2317 | beta-glucuronidase | - |
GS3922_RS17895 | 2361079..2361237 | - | 159 | WP_156487387.1 | hypothetical protein | - |
GS3922_RS11580 | 2361300..2361695 | + | 396 | WP_063167397.1 | nucleotidyltransferase domain-containing protein | Antitoxin |
GS3922_RS11585 | 2361685..2362104 | + | 420 | WP_063166496.1 | DUF86 domain-containing protein | Toxin |
GS3922_RS11590 | 2362132..2362785 | - | 654 | WP_063166497.1 | TetR/AcrR family transcriptional regulator | - |
GS3922_RS11595 | 2362797..2363267 | - | 471 | Protein_2322 | ABC transporter permease | - |
GS3922_RS17315 | 2363195..2363446 | - | 252 | WP_082816565.1 | ATP-binding cassette domain-containing protein | - |
GS3922_RS11600 | 2363471..2364676 | - | 1206 | WP_063166498.1 | DUF3533 domain-containing protein | - |
GS3922_RS11605 | 2364814..2365329 | - | 516 | WP_063166499.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15933.38 Da Isoelectric Point: 7.4011
>T60747 WP_063166496.1 NZ_CP014342:2361685-2362104 [Geobacillus subterraneus]
MKSDVILNKISVIERCLKRIREEYNGDPKNLQNYTKQDSIVLNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFALLEEH
GVISPSVSKKMKAMIGFRNIAVHDYQQLNLGIVQAIVEHHLDDFKQFAEAILRYAKENN
MKSDVILNKISVIERCLKRIREEYNGDPKNLQNYTKQDSIVLNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFALLEEH
GVISPSVSKKMKAMIGFRNIAVHDYQQLNLGIVQAIVEHHLDDFKQFAEAILRYAKENN
Download Length: 420 bp
>T60747 NZ_CP014342:2361685-2362104 [Geobacillus subterraneus]
ATGAAAAGTGATGTCATTTTAAACAAGATCAGCGTGATCGAACGCTGCCTGAAACGAATTCGTGAAGAATATAACGGCGA
TCCAAAAAATTTACAAAATTACACAAAACAAGATTCGATCGTTCTGAATTTACAGCGGGCGTGCGAAGCCTGCATCGATT
TGGCCATGCATATCGTTGCCGAGCAAAAATTCGGATTGCCGCAGCATAGCCGCGATGCGTTCGCTCTTCTCGAAGAACAT
GGGGTCATCTCCCCTTCCGTAAGCAAAAAGATGAAGGCGATGATCGGATTCCGCAACATCGCTGTTCACGACTACCAACA
ACTGAACCTCGGCATCGTGCAAGCCATCGTTGAACACCATCTTGATGATTTCAAACAGTTTGCCGAAGCTATCCTCCGTT
ATGCGAAAGAAAACAACTAG
ATGAAAAGTGATGTCATTTTAAACAAGATCAGCGTGATCGAACGCTGCCTGAAACGAATTCGTGAAGAATATAACGGCGA
TCCAAAAAATTTACAAAATTACACAAAACAAGATTCGATCGTTCTGAATTTACAGCGGGCGTGCGAAGCCTGCATCGATT
TGGCCATGCATATCGTTGCCGAGCAAAAATTCGGATTGCCGCAGCATAGCCGCGATGCGTTCGCTCTTCTCGAAGAACAT
GGGGTCATCTCCCCTTCCGTAAGCAAAAAGATGAAGGCGATGATCGGATTCCGCAACATCGCTGTTCACGACTACCAACA
ACTGAACCTCGGCATCGTGCAAGCCATCGTTGAACACCATCTTGATGATTTCAAACAGTTTGCCGAAGCTATCCTCCGTT
ATGCGAAAGAAAACAACTAG
Antitoxin
Download Length: 132 a.a. Molecular weight: 14789.94 Da Isoelectric Point: 4.9943
>AT60747 WP_063167397.1 NZ_CP014342:2361300-2361695 [Geobacillus subterraneus]
METVIIQTLRPVLDPFVIYLFGSAARGAMRPDSDVDIAFVSDGEPHDPYELFRLAGHLADKLGRDVDLVDLRQASTVFQA
QVVSTGKAIDCRDERKRAEFEMKTLKMYVKLNEERAPVLKQITESGSIYEK
METVIIQTLRPVLDPFVIYLFGSAARGAMRPDSDVDIAFVSDGEPHDPYELFRLAGHLADKLGRDVDLVDLRQASTVFQA
QVVSTGKAIDCRDERKRAEFEMKTLKMYVKLNEERAPVLKQITESGSIYEK
Download Length: 396 bp
>AT60747 NZ_CP014342:2361300-2361695 [Geobacillus subterraneus]
ATGGAGACGGTCATCATTCAGACCCTCCGTCCGGTTCTTGACCCGTTCGTCATTTATCTGTTCGGTTCAGCCGCCCGTGG
GGCGATGCGCCCGGACAGTGATGTCGATATCGCCTTTGTCAGCGACGGCGAACCGCATGATCCGTATGAGCTGTTTCGGC
TCGCGGGGCATTTGGCTGACAAGTTAGGGCGAGATGTCGATCTTGTCGATTTGCGCCAAGCCAGCACCGTGTTTCAAGCG
CAAGTCGTCTCGACGGGAAAAGCCATTGATTGCCGCGACGAGCGGAAACGGGCTGAGTTCGAAATGAAAACATTGAAAAT
GTATGTGAAACTAAACGAAGAAAGAGCGCCGGTGTTAAAACAAATTACGGAAAGCGGGAGCATATATGAAAAGTGA
ATGGAGACGGTCATCATTCAGACCCTCCGTCCGGTTCTTGACCCGTTCGTCATTTATCTGTTCGGTTCAGCCGCCCGTGG
GGCGATGCGCCCGGACAGTGATGTCGATATCGCCTTTGTCAGCGACGGCGAACCGCATGATCCGTATGAGCTGTTTCGGC
TCGCGGGGCATTTGGCTGACAAGTTAGGGCGAGATGTCGATCTTGTCGATTTGCGCCAAGCCAGCACCGTGTTTCAAGCG
CAAGTCGTCTCGACGGGAAAAGCCATTGATTGCCGCGACGAGCGGAAACGGGCTGAGTTCGAAATGAAAACATTGAAAAT
GTATGTGAAACTAAACGAAGAAAGAGCGCCGGTGTTAAAACAAATTACGGAAAGCGGGAGCATATATGAAAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A143MK67 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A143MN77 |