Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 1128297..1129531 Replicon chromosome
Accession NZ_CP014326
Organism Streptococcus mitis strain SVGS_061

Toxin (Protein)


Gene name zeta Uniprot ID A0A110A1D0
Locus tag AXK38_RS05470 Protein ID WP_061088012.1
Coordinates 1128773..1129531 (+) Length 253 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID B6ZCC4
Locus tag AXK38_RS05465 Protein ID WP_000579612.1
Coordinates 1128297..1128773 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXK38_RS05435 1123407..1123655 + 249 WP_001814254.1 hypothetical protein -
AXK38_RS05440 1123826..1124545 + 720 Protein_1001 type A chloramphenicol O-acetyltransferase -
AXK38_RS05445 1125341..1126264 - 924 WP_061088011.1 protein rep -
AXK38_RS05450 1126468..1127298 + 831 Protein_1003 alpha-glycosidase -
AXK38_RS11455 1127566..1128021 + 456 Protein_1004 hypothetical protein -
AXK38_RS05465 1128297..1128773 + 477 WP_000579612.1 helix-turn-helix domain-containing protein Antitoxin
AXK38_RS05470 1128773..1129531 + 759 WP_061088012.1 zeta toxin family protein Toxin
AXK38_RS05475 1129998..1131344 + 1347 WP_049534637.1 ATP-binding protein -
AXK38_RS05480 1131337..1132089 + 753 WP_061088013.1 hypothetical protein -
AXK38_RS10560 1132181..1132645 - 465 Protein_1009 IS30 family transposase -
AXK38_RS10565 1132949..1133347 - 399 WP_061088014.1 hypothetical protein -
AXK38_RS05490 1133548..1133880 + 333 WP_000656276.1 LytTR family transcriptional regulator DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 253 a.a.        Molecular weight: 28715.50 Da        Isoelectric Point: 6.8504

>T60745 WP_061088012.1 NZ_CP014326:1128773-1129531 [Streptococcus mitis]
VEIQDYTDSEFKHALARNLRSLTRGQKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPRYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTVDVPKKTAQLLKNQGYEVQLALIATKPELSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCIYDSGEDKTSAATVLHDLLFGEWNQVEKEML
KSGGERLKDLTN

Download         Length: 759 bp

>T60745 NZ_CP014326:1128773-1129531 [Streptococcus mitis]
GTGGAAATCCAAGATTATACTGACAGTGAATTCAAACATGCTCTAGCGCGGAACCTTCGCTCACTGACAAGAGGACAAAA
GTCCAGTAAGCAGCCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAAACTACAATTCATCGGATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGCGATAGTTTTCGTTCTCAGCATCCACGCTATTTAGAACTGCAGCAA
GAATATGGTAAAGACAGTGTAGAATACACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATC
AGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAGCCCGAATTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTATATATGATTCAG
GAGAAGATAAAACTTCAGCAGCAACCGTTCTTCATGATTTACTATTTGGAGAATGGAATCAAGTGGAGAAAGAGATGCTT
AAATCTGGAGGAGAAAGATTGAAAGATTTAACTAATTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18245.68 Da        Isoelectric Point: 4.4188

>AT60745 WP_000579612.1 NZ_CP014326:1128297-1128773 [Streptococcus mitis]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT60745 NZ_CP014326:1128297-1128773 [Streptococcus mitis]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGACTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTTTTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A110A1D0

Antitoxin

Source ID Structure
AlphaFold DB B6ZCC4

References