Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 1120670..1121904 Replicon chromosome
Accession NZ_CP014326
Organism Streptococcus mitis strain SVGS_061

Toxin (Protein)


Gene name pezT Uniprot ID A0A0X8UV02
Locus tag AXK38_RS05425 Protein ID WP_061088009.1
Coordinates 1121146..1121904 (+) Length 253 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID B6ZCC4
Locus tag AXK38_RS05420 Protein ID WP_000579612.1
Coordinates 1120670..1121146 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXK38_RS05385 1115833..1116717 - 885 WP_000583376.1 Rgg/GadR/MutR family transcriptional regulator -
AXK38_RS05395 1117892..1118533 + 642 WP_000933083.1 hypothetical protein -
AXK38_RS05400 1118543..1119628 + 1086 WP_050215984.1 toprim domain-containing protein -
AXK38_RS05405 1119679..1119912 + 234 WP_000152419.1 hypothetical protein -
AXK38_RS05410 1119909..1120292 + 384 WP_000159212.1 hypothetical protein -
AXK38_RS05415 1120330..1120602 + 273 WP_000495438.1 hypothetical protein -
AXK38_RS05420 1120670..1121146 + 477 WP_000579612.1 helix-turn-helix domain-containing protein Antitoxin
AXK38_RS05425 1121146..1121904 + 759 WP_061088009.1 zeta toxin family protein Toxin
AXK38_RS05430 1122380..1123168 + 789 WP_061088010.1 hypothetical protein -
AXK38_RS05435 1123407..1123655 + 249 WP_001814254.1 hypothetical protein -
AXK38_RS05440 1123826..1124545 + 720 Protein_1001 type A chloramphenicol O-acetyltransferase -
AXK38_RS05445 1125341..1126264 - 924 WP_061088011.1 protein rep -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 253 a.a.        Molecular weight: 28748.57 Da        Isoelectric Point: 6.7647

>T60744 WP_061088009.1 NZ_CP014326:1121146-1121904 [Streptococcus mitis]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPRYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTVDVPKKTAQLLKNQGYEVQLALIATKPELSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAADVLQELLFGEWSQVEKDML
KSGEERLKDLTN

Download         Length: 759 bp

>T60744 NZ_CP014326:1121146-1121904 [Streptococcus mitis]
GTGGAAATCCAAGATTATACTGACAGTGAATTCAAACATGCTCTAGCGCGGAACCTTCGCTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAGCCTATAGCGATTTTGCTCGGAGGGCAAAGTGGTGCCGGTAAAACTACAATTCATCGGATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGCGATAGTTTTCGTTCTCAGCATCCACGCTATTTAGAACTGCAGCAA
GAATATGGTAAAGACAGTGTAGAATACACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGGGATACAATCTTTTGATAGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATC
AGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAGCCCGAATTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAGGTTGTGTATATGATGCAA
AAGAAAATACAACTTCAGCGGCAGATGTTCTTCAAGAGTTACTGTTTGGGGAGTGGAGTCAAGTAGAGAAGGATATGCTT
AAATCTGGAGAAGAAAGATTGAAAGATTTAACTAATTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18245.68 Da        Isoelectric Point: 4.4188

>AT60744 WP_000579612.1 NZ_CP014326:1120670-1121146 [Streptococcus mitis]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT60744 NZ_CP014326:1120670-1121146 [Streptococcus mitis]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACCGAATTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGACTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTTTTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8UV02

Antitoxin

Source ID Structure
AlphaFold DB B6ZCC4

References