60743

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 522777..523404 Replicon chromosome
Accession NZ_CP014326
Organism Streptococcus mitis strain SVGS_061

Toxin (Protein)


Gene name parE Uniprot ID A0A0X8UU21
Locus tag AXK38_RS02835 Protein ID WP_061087703.1
Coordinates 523054..523404 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A081QFE7
Locus tag AXK38_RS02830 Protein ID WP_033683246.1
Coordinates 522777..523064 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXK38_RS02805 518343..519182 + 840 WP_001192009.1 carbohydrate ABC transporter permease -
AXK38_RS02810 519308..519760 + 453 WP_061087699.1 YhcH/YjgK/YiaL family protein -
AXK38_RS02815 520043..520687 + 645 WP_061087700.1 YesL family protein -
AXK38_RS02820 520861..521778 + 918 WP_061087701.1 dihydrodipicolinate synthase family protein -
AXK38_RS02825 521796..522680 + 885 WP_061087702.1 ROK family protein -
AXK38_RS02830 522777..523064 + 288 WP_033683246.1 XRE family transcriptional regulator Antitoxin
AXK38_RS02835 523054..523404 + 351 WP_061087703.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AXK38_RS02840 523466..524317 - 852 WP_061087704.1 MurR/RpiR family transcriptional regulator -
AXK38_RS02845 524511..526568 + 2058 WP_081097309.1 penicillin-binding protein 2B -
AXK38_RS02850 526579..527175 + 597 WP_000966748.1 recombination mediator RecR -
AXK38_RS02855 527351..528394 + 1044 WP_061087706.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13778.96 Da        Isoelectric Point: 9.8158

>T60743 WP_061087703.1 NZ_CP014326:523054-523404 [Streptococcus mitis]
MDYKKYRILYSPRVIDSLDKIYQYIAEEIGFVEAARRKVASIRKDINRLEIFPQAGFDADEKFGKKLDPRYQTRGLTLSK
DYIVLYTIVEDTVRLAYLLPSKSDYMKLFKTKSRYD

Download         Length: 351 bp

>T60743 NZ_CP014326:523054-523404 [Streptococcus mitis]
ATGGATTATAAAAAATATAGGATTTTGTATTCTCCTAGAGTGATTGATAGTCTGGATAAAATATATCAGTATATAGCGGA
GGAAATCGGTTTTGTAGAGGCTGCGAGAAGAAAAGTGGCGAGTATCAGAAAAGATATTAATCGTCTAGAAATTTTCCCCC
AAGCTGGATTTGATGCCGATGAAAAATTTGGTAAGAAATTAGACCCTCGCTACCAAACGCGAGGATTGACCTTGAGTAAG
GATTACATCGTATTATATACAATTGTTGAGGATACCGTCAGACTTGCTTATTTACTCCCTTCAAAAAGTGATTACATGAA
ATTATTCAAGACTAAGTCAAGATACGACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10776.20 Da        Isoelectric Point: 4.1835

>AT60743 WP_033683246.1 NZ_CP014326:522777-523064 [Streptococcus mitis]
MAIANSSKMVTFQANRELVNDAMEVLKEQNLSLSSALRLFLKNVVVTNGVDLLSEEELEKEYLFRQLQAEVQESYAKIEA
GNYLTDEDVVTRYGL

Download         Length: 288 bp

>AT60743 NZ_CP014326:522777-523064 [Streptococcus mitis]
ATGGCTATAGCGAATTCAAGTAAAATGGTAACCTTCCAAGCTAATAGAGAATTGGTAAACGATGCTATGGAAGTGTTAAA
AGAACAAAATCTCTCTCTTTCATCAGCACTCAGATTATTTTTAAAGAATGTTGTCGTAACAAATGGAGTAGATTTACTGA
GTGAAGAGGAATTAGAGAAGGAGTATTTGTTTAGACAATTACAAGCAGAAGTTCAAGAAAGTTATGCCAAGATTGAGGCT
GGAAATTACTTGACAGATGAGGATGTCGTGACACGCTATGGATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8UU21

Antitoxin

Source ID Structure
AlphaFold DB A0A081QFE7

References