Detailed information of TA system TA060721

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4977275..4978095
• Replicon: chromosome
• Accession: NZ_CP014316
• Organism: Escherichia coli JJ1887

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: AX202_RS24940
• Protein ID: WP_001054379.1
• Coordinates: 4977838..4978095 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: AX202_RS24935
• Protein ID: WP_000123957.1
• Coordinates: 4977275..4977826 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AX202_RS24910	4972969..4974282	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
AX202_RS24915	4974294..4974572	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
AX202_RS24920	4974569..4975690	-	1122	WP_000010833.1	M42 family metallopeptidase	-
AX202_RS30615	4975935..4976051	-	117	Protein_4743	VOC family protein	-
AX202_RS24925	4976089..4976349	-	261	WP_000077645.1	hypothetical protein	-
AX202_RS24930	4976477..4977223	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
AX202_RS24935	4977275..4977826	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
AX202_RS24940	4977838..4978095	-	258	WP_001054379.1	YjhX family toxin	Toxin
AX202_RS28665	4978472..4978636	-	165	Protein_4748	GNAT family N-acetyltransferase	-
AX202_RS24955	4979879..4980985	+	1107	Protein_4750	helicase YjhR	-
AX202_RS24960	4981568..4982548	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T60721 WP_001054379.1 NZ_CP014316:c4978095-4977838 [Escherichia coli JJ1887]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T60721 NZ_CP014316:c4978095-4977838 [Escherichia coli JJ1887]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT60721 WP_000123957.1 NZ_CP014316:c4977826-4977275 [Escherichia coli JJ1887]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT60721 NZ_CP014316:c4977826-4977275 [Escherichia coli JJ1887]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030