Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3261536..3262190 Replicon chromosome
Accession NZ_CP014316
Organism Escherichia coli JJ1887

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag AX202_RS16405 Protein ID WP_000244765.1
Coordinates 3261536..3261943 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag AX202_RS16410 Protein ID WP_000354050.1
Coordinates 3261924..3262190 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AX202_RS16385 3257493..3259226 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
AX202_RS16390 3259232..3259942 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AX202_RS16395 3259967..3260863 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
AX202_RS16400 3260975..3261496 + 522 WP_001055874.1 flavodoxin FldB -
AX202_RS16405 3261536..3261943 - 408 WP_000244765.1 protein YgfX Toxin
AX202_RS16410 3261924..3262190 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
AX202_RS16415 3262433..3263413 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
AX202_RS16420 3263490..3264149 - 660 WP_000250275.1 hemolysin III family protein -
AX202_RS16425 3264313..3264624 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
AX202_RS16430 3264669..3266102 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T60712 WP_000244765.1 NZ_CP014316:c3261943-3261536 [Escherichia coli JJ1887]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T60712 NZ_CP014316:c3261943-3261536 [Escherichia coli JJ1887]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT60712 WP_000354050.1 NZ_CP014316:c3262190-3261924 [Escherichia coli JJ1887]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT60712 NZ_CP014316:c3262190-3261924 [Escherichia coli JJ1887]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References