Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2749146..2749624 Replicon chromosome
Accession NZ_CP014314
Organism Escherichia coli O157:H7 strain JEONG-1266

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag JEONG1266_RS14825 Protein ID WP_001303876.1
Coordinates 2749337..2749624 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag JEONG1266_RS14820 Protein ID WP_000536233.1
Coordinates 2749146..2749337 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JEONG1266_RS14785 2744550..2745320 - 771 WP_000450992.1 DUF1627 domain-containing protein -
JEONG1266_RS14790 2745342..2746088 - 747 WP_000788745.1 ATP-binding protein -
JEONG1266_RS14795 2746095..2747186 - 1092 WP_001205823.1 hypothetical protein -
JEONG1266_RS31635 2747265..2747720 + 456 WP_000273724.1 hypothetical protein -
JEONG1266_RS14805 2747927..2748352 - 426 WP_000693855.1 Rha family transcriptional regulator -
JEONG1266_RS14810 2748336..2748608 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
JEONG1266_RS14815 2748717..2749118 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
JEONG1266_RS14820 2749146..2749337 + 192 WP_000536233.1 hypothetical protein Antitoxin
JEONG1266_RS14825 2749337..2749624 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JEONG1266_RS14830 2749902..2750057 + 156 WP_000379575.1 DUF1391 family protein -
JEONG1266_RS14835 2750199..2750588 + 390 WP_000394511.1 hypothetical protein -
JEONG1266_RS14840 2750775..2750960 - 186 WP_001133046.1 hypothetical protein -
JEONG1266_RS31650 2751534..2751722 + 189 WP_000413705.1 cell division inhibition protein DicB -
JEONG1266_RS14855 2751719..2751910 + 192 WP_001098307.1 DUF1482 family protein -
JEONG1266_RS14860 2752004..2754475 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T60676 WP_001303876.1 NZ_CP014314:2749337-2749624 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T60676 NZ_CP014314:2749337-2749624 [Escherichia coli O157:H7]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT60676 WP_000536233.1 NZ_CP014314:2749146-2749337 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT60676 NZ_CP014314:2749146-2749337 [Escherichia coli O157:H7]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References