60656

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 369951..370513 Replicon plasmid unnamed3
Accession NZ_CP014310
Organism Burkholderia sp. PAMC 26561

Toxin (Protein)


Gene name mazF Uniprot ID A0A125SHY9
Locus tag AXG89_RS32295 Protein ID WP_062174692.1
Coordinates 369951..370199 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A125SHZ0
Locus tag AXG89_RS32300 Protein ID WP_062174693.1
Coordinates 370193..370513 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXG89_RS32265 365367..366137 + 771 WP_062174688.1 IS21-like element helper ATPase IstB -
AXG89_RS32270 366252..366626 - 375 Protein_343 IS21 family transposase -
AXG89_RS32280 366745..367512 + 768 WP_082771728.1 IS21-like element helper ATPase IstB -
AXG89_RS32290 369184..369867 + 684 WP_082771697.1 site-specific integrase -
AXG89_RS32295 369951..370199 + 249 WP_062174692.1 antitoxin Toxin
AXG89_RS32300 370193..370513 + 321 WP_062174693.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
AXG89_RS32305 370577..371011 + 435 WP_062174695.1 hypothetical protein -
AXG89_RS42550 371205..371390 - 186 WP_162916189.1 hypothetical protein -
AXG89_RS32325 373462..374485 + 1024 Protein_351 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..601076 601076


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(3-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8927.19 Da        Isoelectric Point: 4.2821

>T60656 WP_062174692.1 NZ_CP014310:369951-370199 [Burkholderia sp. PAMC 26561]
MKTVIRKMGNSQGILIPKPILAQLGFEDEVDMEVVDESIVLRRPSPKVRAGWAQASKEIAGSNDDALVMGEFANDGDAEL
AW

Download         Length: 249 bp

>T60656 NZ_CP014310:369951-370199 [Burkholderia sp. PAMC 26561]
ATGAAAACGGTAATTCGGAAAATGGGCAATTCCCAGGGGATTTTGATTCCCAAGCCAATTTTGGCCCAACTTGGGTTCGA
GGATGAGGTAGACATGGAAGTTGTGGATGAGTCGATCGTGCTGCGGCGTCCATCGCCAAAAGTACGCGCTGGCTGGGCGC
AAGCTAGCAAGGAGATTGCAGGCTCGAACGATGACGCCTTGGTAATGGGGGAGTTCGCTAATGATGGTGACGCGGAGCTT
GCATGGTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11731.98 Da        Isoelectric Point: 10.6093

>AT60656 WP_062174693.1 NZ_CP014310:370193-370513 [Burkholderia sp. PAMC 26561]
MVKRGEVWLVALDPTIGSEIQKTRPCLIVSPPEMHDHLKTVLVAPMTSKGRSAPFRVPVSFAKTDGLILLDQMRAVDKKR
LVKKAGVIADNTLLKALRTLQEVFAE

Download         Length: 321 bp

>AT60656 NZ_CP014310:370193-370513 [Burkholderia sp. PAMC 26561]
ATGGTGAAGCGAGGAGAGGTTTGGCTTGTCGCTCTTGACCCGACTATTGGTAGCGAAATTCAAAAGACTCGCCCGTGTTT
GATCGTCTCGCCGCCCGAGATGCATGACCATCTTAAGACCGTACTTGTCGCGCCGATGACCAGCAAAGGTAGGTCGGCTC
CCTTTCGAGTGCCGGTTTCATTCGCCAAAACGGACGGATTAATACTGCTGGATCAAATGCGCGCCGTCGATAAGAAGCGT
CTGGTAAAGAAAGCTGGCGTGATTGCCGATAACACATTGTTGAAGGCTCTACGAACGCTGCAGGAAGTTTTCGCGGAATA
G

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A125SHY9

Antitoxin

Source ID Structure
AlphaFold DB A0A125SHZ0

References