Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 528923..529848 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP014309 | ||
| Organism | Burkholderia sp. PAMC 26561 | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | A0A109WV41 |
| Locus tag | AXG89_RS29210 | Protein ID | WP_062173350.1 |
| Coordinates | 529327..529848 (+) | Length | 174 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | A0A120KZ63 |
| Locus tag | AXG89_RS29205 | Protein ID | WP_062173352.1 |
| Coordinates | 528923..529330 (+) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AXG89_RS29175 | 524323..524643 | - | 321 | WP_062173360.1 | CcdB family protein | - |
| AXG89_RS29180 | 524643..524909 | - | 267 | WP_082771595.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| AXG89_RS29185 | 525346..526473 | + | 1128 | WP_062173358.1 | AAA family ATPase | - |
| AXG89_RS29190 | 526481..527110 | - | 630 | WP_062173356.1 | hypothetical protein | - |
| AXG89_RS29195 | 527271..527639 | - | 369 | WP_082771594.1 | RHS repeat-associated core domain-containing protein | - |
| AXG89_RS29200 | 528039..528344 | - | 306 | WP_062173354.1 | flagellar biosynthesis anti-sigma factor FlgM | - |
| AXG89_RS29205 | 528923..529330 | + | 408 | WP_062173352.1 | hypothetical protein | Antitoxin |
| AXG89_RS29210 | 529327..529848 | + | 522 | WP_062173350.1 | RES family NAD+ phosphorylase | Toxin |
| AXG89_RS29215 | 530209..530445 | + | 237 | WP_062173348.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| AXG89_RS29220 | 530442..530780 | + | 339 | WP_062173346.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| AXG89_RS29225 | 531954..533462 | + | 1509 | WP_205583095.1 | sigma 54-interacting transcriptional regulator | - |
| AXG89_RS29230 | 533750..534235 | + | 486 | WP_082771651.1 | OsmC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | katA | 1..793876 | 793876 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 174 a.a. Molecular weight: 19327.90 Da Isoelectric Point: 5.5777
>T60653 WP_062173350.1 NZ_CP014309:529327-529848 [Burkholderia sp. PAMC 26561]
MIFANLFNVTVYRMLVPKWAVAPMSGAGAGTHGGRANRVGLNALYLALDHDTAVREYQQLSSLMPPGTLVSYSLTATPIV
DFTGGYESGKWSPLWEDFYCDWRHCWFNERIEPPSWIIGDEVVLSGAKGILFKSRLTPNGTNLVLYTENFDPTDRLDVFD
PHNALPKNQSSWG
MIFANLFNVTVYRMLVPKWAVAPMSGAGAGTHGGRANRVGLNALYLALDHDTAVREYQQLSSLMPPGTLVSYSLTATPIV
DFTGGYESGKWSPLWEDFYCDWRHCWFNERIEPPSWIIGDEVVLSGAKGILFKSRLTPNGTNLVLYTENFDPTDRLDVFD
PHNALPKNQSSWG
Download Length: 522 bp
>T60653 NZ_CP014309:529327-529848 [Burkholderia sp. PAMC 26561]
ATGATTTTTGCGAACCTGTTTAACGTAACCGTATATCGGATGCTCGTCCCGAAGTGGGCAGTCGCGCCGATGAGCGGCGC
TGGAGCAGGAACGCATGGCGGTCGTGCGAATCGTGTCGGACTCAACGCGCTTTACCTCGCATTGGATCACGACACTGCCG
TCAGAGAGTATCAGCAACTCTCGTCCTTGATGCCACCAGGGACGCTGGTTAGCTACAGCCTCACGGCCACCCCTATAGTC
GATTTCACCGGTGGATACGAGAGTGGCAAGTGGTCTCCTTTGTGGGAGGATTTTTATTGCGATTGGCGCCACTGCTGGTT
CAATGAACGGATCGAGCCACCCAGTTGGATCATCGGCGATGAGGTCGTCTTGAGCGGCGCCAAAGGTATCCTCTTCAAAT
CACGACTAACACCTAACGGCACGAATCTCGTTCTGTACACAGAGAATTTCGACCCAACCGATCGTCTCGACGTTTTCGAT
CCGCACAATGCACTACCGAAGAATCAGTCGTCGTGGGGTTGA
ATGATTTTTGCGAACCTGTTTAACGTAACCGTATATCGGATGCTCGTCCCGAAGTGGGCAGTCGCGCCGATGAGCGGCGC
TGGAGCAGGAACGCATGGCGGTCGTGCGAATCGTGTCGGACTCAACGCGCTTTACCTCGCATTGGATCACGACACTGCCG
TCAGAGAGTATCAGCAACTCTCGTCCTTGATGCCACCAGGGACGCTGGTTAGCTACAGCCTCACGGCCACCCCTATAGTC
GATTTCACCGGTGGATACGAGAGTGGCAAGTGGTCTCCTTTGTGGGAGGATTTTTATTGCGATTGGCGCCACTGCTGGTT
CAATGAACGGATCGAGCCACCCAGTTGGATCATCGGCGATGAGGTCGTCTTGAGCGGCGCCAAAGGTATCCTCTTCAAAT
CACGACTAACACCTAACGGCACGAATCTCGTTCTGTACACAGAGAATTTCGACCCAACCGATCGTCTCGACGTTTTCGAT
CCGCACAATGCACTACCGAAGAATCAGTCGTCGTGGGGTTGA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14822.60 Da Isoelectric Point: 5.6485
>AT60653 WP_062173352.1 NZ_CP014309:528923-529330 [Burkholderia sp. PAMC 26561]
MNSNADATVPGADVGFDRFMASLRDPNDPAPIVSARRFGEALHIDLQTLAQQAHVHRNTISRQPASESVQRFLRDALRVI
RAATDLAGDVSKALFWYRNEPLPVFDYKTAEQLVSEGRADDIIRFVASLETGAAG
MNSNADATVPGADVGFDRFMASLRDPNDPAPIVSARRFGEALHIDLQTLAQQAHVHRNTISRQPASESVQRFLRDALRVI
RAATDLAGDVSKALFWYRNEPLPVFDYKTAEQLVSEGRADDIIRFVASLETGAAG
Download Length: 408 bp
>AT60653 NZ_CP014309:528923-529330 [Burkholderia sp. PAMC 26561]
ATGAACTCAAATGCAGATGCGACCGTTCCCGGCGCAGATGTTGGTTTTGATCGATTTATGGCGTCGTTGCGTGACCCAAA
CGACCCCGCACCGATTGTGTCGGCCCGTCGATTCGGCGAGGCTTTGCATATTGACTTGCAGACCCTGGCGCAGCAAGCGC
ACGTGCACCGAAATACGATCAGCAGGCAACCTGCGTCCGAAAGCGTACAACGGTTTCTTCGCGATGCCCTAAGGGTGATC
CGCGCCGCGACTGATCTTGCAGGCGACGTCTCGAAGGCGCTTTTTTGGTACAGAAACGAACCCCTCCCCGTGTTCGACTA
TAAAACCGCCGAACAATTGGTATCCGAAGGTCGGGCCGACGATATCATCCGTTTCGTTGCATCCCTCGAAACGGGCGCGG
CGGGATGA
ATGAACTCAAATGCAGATGCGACCGTTCCCGGCGCAGATGTTGGTTTTGATCGATTTATGGCGTCGTTGCGTGACCCAAA
CGACCCCGCACCGATTGTGTCGGCCCGTCGATTCGGCGAGGCTTTGCATATTGACTTGCAGACCCTGGCGCAGCAAGCGC
ACGTGCACCGAAATACGATCAGCAGGCAACCTGCGTCCGAAAGCGTACAACGGTTTCTTCGCGATGCCCTAAGGGTGATC
CGCGCCGCGACTGATCTTGCAGGCGACGTCTCGAAGGCGCTTTTTTGGTACAGAAACGAACCCCTCCCCGTGTTCGACTA
TAAAACCGCCGAACAATTGGTATCCGAAGGTCGGGCCGACGATATCATCCGTTTCGTTGCATCCCTCGAAACGGGCGCGG
CGGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A109WV41 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A120KZ63 |